Association between Metabolic Syndrome and Chronic Kidney Disease in Perimenopausal Women
The purpose of the study was to explore the association between metabolic syndrome (MetS) and chronic kidney disease (CKD) in perimenopausal women. A cross-sectional study was conducted in Zhuhai from June to October 2012. Perimenopausal women (n = 685) were included in the study. All participants w...
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doaj-860992eebcad415b94caddca93ed31112020-11-24T23:09:52ZengMDPI AGInternational Journal of Environmental Research and Public Health1660-46012013-08-011093987399710.3390/ijerph10093987Association between Metabolic Syndrome and Chronic Kidney Disease in Perimenopausal WomenHarry HolthöferHequn ZouQin LiuKangping DengXiaohong WangBin LiHonglei WangYing ZhangXiaofei ShaoAiqun LiuXinyu LiuYouming ChenLiqin ZhaoYongqiang LiThe purpose of the study was to explore the association between metabolic syndrome (MetS) and chronic kidney disease (CKD) in perimenopausal women. A cross-sectional study was conducted in Zhuhai from June to October 2012. Perimenopausal women (n = 685) were included in the study. All participants were divided into three subgroups: Group 1, 40 years old ≤ Age < 50 years old; Group 2, 50 years old ≤ Age < 60 years old; Group 3, 60 years old ≤ Age ≤ 65 years old. MetS was associated with CKD (p < 0.01) in the unadjusted analyses in total subjects. After adjusting the potential confounders, the odd ratios of CKD for MetS was 2.66 (95% CI 1.56 to 4.49, p < 0.001). There was no relationship between MetS and CKD in both Group 1 and Group 3. MetS was associated with CKD (p < 0.001) in the unadjusted analyses in Group 2. After adjusting for potential confounders, MetS was significantly associated with CKD. The odd ratios for MetS was 6.79 (95% CI 2.30 to 20.09, p < 0.001). There was no relationship between elevated blood pressure, elevated fasting glucose, abdominal obesity, Low HDL cholesterol, elevated triglycerides and CKD in both Group 1 and Group 3. Elevated blood pressure was associated with CKD in Group 2 (unadjusted Odds ratio: 4.52 (1.28–16.02), p = 0.02). After adjusting for potential confounders, there was no relationship between elevated blood pressure and CKD (p = 0.78). Elevated fasting glucose was associated with CKD in Group 2 (unadjusted Odds ratio: 3.69 (1.10–12.38), p = 0.03). After adjusting for potential confounders, there was no relationship between elevated fasting glucose and CKD (p = 0.15). There was no relationship between abdominal obesity, Low HDL cholesterol, elevated triglycerides and CKD in Group 2. These findings suggest that in perimenopausal women aged from 50 or older to 60 MetS was associated with CKD. There is no relationship between MetS and CKD in perimenopausal women aged from 40 or older to 50 and aged from 60 or older to 65.http://www.mdpi.com/1660-4601/10/9/3987metabolic syndromechronic kidney diseaseperimenopausal women |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Harry Holthöfer Hequn Zou Qin Liu Kangping Deng Xiaohong Wang Bin Li Honglei Wang Ying Zhang Xiaofei Shao Aiqun Liu Xinyu Liu Youming Chen Liqin Zhao Yongqiang Li |
spellingShingle |
Harry Holthöfer Hequn Zou Qin Liu Kangping Deng Xiaohong Wang Bin Li Honglei Wang Ying Zhang Xiaofei Shao Aiqun Liu Xinyu Liu Youming Chen Liqin Zhao Yongqiang Li Association between Metabolic Syndrome and Chronic Kidney Disease in Perimenopausal Women International Journal of Environmental Research and Public Health metabolic syndrome chronic kidney disease perimenopausal women |
author_facet |
Harry Holthöfer Hequn Zou Qin Liu Kangping Deng Xiaohong Wang Bin Li Honglei Wang Ying Zhang Xiaofei Shao Aiqun Liu Xinyu Liu Youming Chen Liqin Zhao Yongqiang Li |
author_sort |
Harry Holthöfer |
title |
Association between Metabolic Syndrome and Chronic Kidney Disease in Perimenopausal Women |
title_short |
Association between Metabolic Syndrome and Chronic Kidney Disease in Perimenopausal Women |
title_full |
Association between Metabolic Syndrome and Chronic Kidney Disease in Perimenopausal Women |
title_fullStr |
Association between Metabolic Syndrome and Chronic Kidney Disease in Perimenopausal Women |
title_full_unstemmed |
Association between Metabolic Syndrome and Chronic Kidney Disease in Perimenopausal Women |
title_sort |
association between metabolic syndrome and chronic kidney disease in perimenopausal women |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1660-4601 |
publishDate |
2013-08-01 |
description |
The purpose of the study was to explore the association between metabolic syndrome (MetS) and chronic kidney disease (CKD) in perimenopausal women. A cross-sectional study was conducted in Zhuhai from June to October 2012. Perimenopausal women (n = 685) were included in the study. All participants were divided into three subgroups: Group 1, 40 years old ≤ Age < 50 years old; Group 2, 50 years old ≤ Age < 60 years old; Group 3, 60 years old ≤ Age ≤ 65 years old. MetS was associated with CKD (p < 0.01) in the unadjusted analyses in total subjects. After adjusting the potential confounders, the odd ratios of CKD for MetS was 2.66 (95% CI 1.56 to 4.49, p < 0.001). There was no relationship between MetS and CKD in both Group 1 and Group 3. MetS was associated with CKD (p < 0.001) in the unadjusted analyses in Group 2. After adjusting for potential confounders, MetS was significantly associated with CKD. The odd ratios for MetS was 6.79 (95% CI 2.30 to 20.09, p < 0.001). There was no relationship between elevated blood pressure, elevated fasting glucose, abdominal obesity, Low HDL cholesterol, elevated triglycerides and CKD in both Group 1 and Group 3. Elevated blood pressure was associated with CKD in Group 2 (unadjusted Odds ratio: 4.52 (1.28–16.02), p = 0.02). After adjusting for potential confounders, there was no relationship between elevated blood pressure and CKD (p = 0.78). Elevated fasting glucose was associated with CKD in Group 2 (unadjusted Odds ratio: 3.69 (1.10–12.38), p = 0.03). After adjusting for potential confounders, there was no relationship between elevated fasting glucose and CKD (p = 0.15). There was no relationship between abdominal obesity, Low HDL cholesterol, elevated triglycerides and CKD in Group 2. These findings suggest that in perimenopausal women aged from 50 or older to 60 MetS was associated with CKD. There is no relationship between MetS and CKD in perimenopausal women aged from 40 or older to 50 and aged from 60 or older to 65. |
topic |
metabolic syndrome chronic kidney disease perimenopausal women |
url |
http://www.mdpi.com/1660-4601/10/9/3987 |
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