The association between paracetamol use and the risk of asthma, rhinitis and eczema in the Polish population
Introduction A growing number of epidemiological studies suggest that paracetamol, which is commonly used in children, may be a risk factor for asthma, allergic rhinitis, and atopic eczema. Objective The aim of this study was to determine and characterize the correlation between paracetamol use and...
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doaj-860c84d71f1a45cba5236ea1b4939c6a2020-11-24T20:56:09ZengInstitute of Rural HealthAnnals of Agricultural and Environmental Medicine1232-19661898-22632018-09-0125342843210.26444/aaem/8633686336The association between paracetamol use and the risk of asthma, rhinitis and eczema in the Polish populationAgnieszka Lipiec0Zbigniew M. Wawrzyniak1Adam J. Sybilski2Urszula Samolińska-Zawisza3Edyta Krzych - Fałta4Barbara Piekarska5Grażyna Dulny6Bożenna Stankiewicz - Choroszucha7Filip Raciborski8Bolesław Samoliński9Department of the Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, PolandDepartment of the Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, PolandDepartment of the Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, PolandDepartment of the Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, PolandDepartment of the Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, PolandDepartment of the Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, PolandDepartment of the Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, PolandDepartment of the Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, PolandDepartment of the Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, PolandDepartment of the Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, PolandIntroduction A growing number of epidemiological studies suggest that paracetamol, which is commonly used in children, may be a risk factor for asthma, allergic rhinitis, and atopic eczema. Objective The aim of this study was to determine and characterize the correlation between paracetamol use and asthma, allergic rhinitis, and atopic eczema symptoms in the Polish population. Material and methods The study is part of the ECAP project involving the use of the ISAAC and ECRHS questionnaires. Completed questionnaires of 18,617 subjects, including 10,011 (53.8%) females, were analyzed. Children aged 6–7 (n=4,510), adolescents aged 13–14 (n=4,721), and adults aged 20–44 (n=9,386) constituted 24.2%, 25.4%, and 50.4% of respondents, respectively. Study subjects lived in 8 major urban centres and one rural area. The frequency of paracetamol use during the previous 12 months and symptoms of asthma, allergic rhinitis, and atopic eczema during that period were analyzed. Results The use of paracetamol was associated with a significant dose-dependent increase in the risk of asthma symptoms in all evaluated age groups. This was demonstrated via odds ratios (OR) for developing asthma symptoms, including wheezing or whistling in the chest in 6–7-year-olds and exercise-induced shortness of breath in 13–14-year-olds and adults, depending on the frequency of paracetamol use in the previous 12 months, compared to no paracetamol intake during that period. Conclusions The use of paracetamol in the last 12 months was associated with a significant dose-dependent increase in the risk of rhinitis and skin allergy symptoms, as demonstrated by the odds ratio. Therefore, frequent paracetamol use may be a risk factor for symptoms of asthma, rhinitis, and skin allergy in the Polish population.http://www.journalssystem.com/aaem/The-association-between-paracetamol-use-and-the-risk-of-asthma-rhinitis-and-eczema,86336,0,2.htmlasthmaRhinitiseczemaparacetamol |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Agnieszka Lipiec Zbigniew M. Wawrzyniak Adam J. Sybilski Urszula Samolińska-Zawisza Edyta Krzych - Fałta Barbara Piekarska Grażyna Dulny Bożenna Stankiewicz - Choroszucha Filip Raciborski Bolesław Samoliński |
spellingShingle |
Agnieszka Lipiec Zbigniew M. Wawrzyniak Adam J. Sybilski Urszula Samolińska-Zawisza Edyta Krzych - Fałta Barbara Piekarska Grażyna Dulny Bożenna Stankiewicz - Choroszucha Filip Raciborski Bolesław Samoliński The association between paracetamol use and the risk of asthma, rhinitis and eczema in the Polish population Annals of Agricultural and Environmental Medicine asthma Rhinitis eczema paracetamol |
author_facet |
Agnieszka Lipiec Zbigniew M. Wawrzyniak Adam J. Sybilski Urszula Samolińska-Zawisza Edyta Krzych - Fałta Barbara Piekarska Grażyna Dulny Bożenna Stankiewicz - Choroszucha Filip Raciborski Bolesław Samoliński |
author_sort |
Agnieszka Lipiec |
title |
The association between paracetamol use and the risk of asthma, rhinitis and eczema in the Polish population |
title_short |
The association between paracetamol use and the risk of asthma, rhinitis and eczema in the Polish population |
title_full |
The association between paracetamol use and the risk of asthma, rhinitis and eczema in the Polish population |
title_fullStr |
The association between paracetamol use and the risk of asthma, rhinitis and eczema in the Polish population |
title_full_unstemmed |
The association between paracetamol use and the risk of asthma, rhinitis and eczema in the Polish population |
title_sort |
association between paracetamol use and the risk of asthma, rhinitis and eczema in the polish population |
publisher |
Institute of Rural Health |
series |
Annals of Agricultural and Environmental Medicine |
issn |
1232-1966 1898-2263 |
publishDate |
2018-09-01 |
description |
Introduction
A growing number of epidemiological studies suggest that paracetamol, which is commonly used in children, may be a risk factor for asthma, allergic rhinitis, and atopic eczema.
Objective
The aim of this study was to determine and characterize the correlation between paracetamol use and asthma, allergic rhinitis, and atopic eczema symptoms in the Polish population.
Material and methods
The study is part of the ECAP project involving the use of the ISAAC and ECRHS questionnaires. Completed questionnaires of 18,617 subjects, including 10,011 (53.8%) females, were analyzed. Children aged 6–7 (n=4,510), adolescents aged 13–14 (n=4,721), and adults aged 20–44 (n=9,386) constituted 24.2%, 25.4%, and 50.4% of respondents, respectively. Study subjects lived in 8 major urban centres and one rural area. The frequency of paracetamol use during the previous 12 months and symptoms of asthma, allergic rhinitis, and atopic eczema during that period were analyzed.
Results
The use of paracetamol was associated with a significant dose-dependent increase in the risk of asthma symptoms in all evaluated age groups. This was demonstrated via odds ratios (OR) for developing asthma symptoms, including wheezing or whistling in the chest in 6–7-year-olds and exercise-induced shortness of breath in 13–14-year-olds and adults, depending on the frequency of paracetamol use in the previous 12 months, compared to no paracetamol intake during that period.
Conclusions
The use of paracetamol in the last 12 months was associated with a significant dose-dependent increase in the risk of rhinitis and skin allergy symptoms, as demonstrated by the odds ratio. Therefore, frequent paracetamol use may be a risk factor for symptoms of asthma, rhinitis, and skin allergy in the Polish population. |
topic |
asthma Rhinitis eczema paracetamol |
url |
http://www.journalssystem.com/aaem/The-association-between-paracetamol-use-and-the-risk-of-asthma-rhinitis-and-eczema,86336,0,2.html |
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