Blockade of Stromal Gas6 Alters Cancer Cell Plasticity, Activates NK Cells, and Inhibits Pancreatic Cancer Metastasis

Blockade of Stromal Gas6 Alters Cancer Cell Plasticity, Activates NK Cells, and Inhibits Pancreatic Cancer Metastasis

Pancreatic ductal adenocarcinoma (PDA) is one of the deadliest cancers due to its aggressive and metastatic nature. PDA is characterized by a rich tumor stroma with abundant macrophages, fibroblasts, and collagen deposition that can represent up to 90% of the tumor mass. Activation of the tyrosine k...

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Bibliographic Details
Main Authors: Lucy Ireland, Teifion Luckett, Michael C. Schmid, Ainhoa Mielgo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
Gas6
pancreatic cancer
metastasis
macrophages
fibroblasts
NK cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00297/full

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