Syndrome of Undifferentiated Recurrent Fever (SURF): An Emerging Group of Autoinflammatory Recurrent Fevers

Syndrome of Undifferentiated Recurrent Fever (SURF): An Emerging Group of Autoinflammatory Recurrent Fevers

Syndrome of undifferentiated recurrent fever (SURF) is a heterogeneous group of autoinflammatory diseases (AID) characterized by self-limiting episodes of systemic inflammation without a confirmed molecular diagnosis, not fulfilling the criteria for periodic fever, aphthous stomatitis, pharyngitis a...

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Main Authors: Riccardo Papa, Federica Penco, Stefano Volpi, Diana Sutera, Roberta Caorsi, Marco Gattorno
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Journal of Clinical Medicine
Subjects:
autoinflammatory diseases
NGS
SURF
FMF
colchicine
anakinra
Online Access:https://www.mdpi.com/2077-0383/10/9/1963
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spelling doaj-86182fe8ed31433cac141d3f2545f07e2021-05-31T23:08:50ZengMDPI AGJournal of Clinical Medicine2077-03832021-05-01101963196310.3390/jcm10091963Syndrome of Undifferentiated Recurrent Fever (SURF): An Emerging Group of Autoinflammatory Recurrent FeversRiccardo Papa0Federica Penco1Stefano Volpi2Diana Sutera3Roberta Caorsi4Marco Gattorno5Center for Autoinflammatory Diseases and Immunodeficiencies, IRCCS Istituto Giannina Gaslini, 16147 Genoa, ItalyCenter for Autoinflammatory Diseases and Immunodeficiencies, IRCCS Istituto Giannina Gaslini, 16147 Genoa, ItalyCenter for Autoinflammatory Diseases and Immunodeficiencies, IRCCS Istituto Giannina Gaslini, 16147 Genoa, ItalyCenter for Autoinflammatory Diseases and Immunodeficiencies, IRCCS Istituto Giannina Gaslini, 16147 Genoa, ItalyCenter for Autoinflammatory Diseases and Immunodeficiencies, IRCCS Istituto Giannina Gaslini, 16147 Genoa, ItalyCenter for Autoinflammatory Diseases and Immunodeficiencies, IRCCS Istituto Giannina Gaslini, 16147 Genoa, ItalySyndrome of undifferentiated recurrent fever (SURF) is a heterogeneous group of autoinflammatory diseases (AID) characterized by self-limiting episodes of systemic inflammation without a confirmed molecular diagnosis, not fulfilling the criteria for periodic fever, aphthous stomatitis, pharyngitis and adenopathy (PFAPA) syndrome. In this review, we focused on the studies enrolling patients suspected of AID and genotyped them with next generation sequencing technologies in order to describe the clinical manifestations and treatment response of published cohorts of patients with SURF. We also propose a preliminary set of indications for the clinical suspicion of SURF that could help in everyday clinical practice.https://www.mdpi.com/2077-0383/10/9/1963autoinflammatory diseasesNGSSURFFMFcolchicineanakinra
collection DOAJ
language English
format Article
sources DOAJ
author Riccardo Papa
Federica Penco
Stefano Volpi
Diana Sutera
Roberta Caorsi
Marco Gattorno
spellingShingle Riccardo Papa
Federica Penco
Stefano Volpi
Diana Sutera
Roberta Caorsi
Marco Gattorno
Syndrome of Undifferentiated Recurrent Fever (SURF): An Emerging Group of Autoinflammatory Recurrent Fevers
Journal of Clinical Medicine
autoinflammatory diseases
NGS
SURF
FMF
colchicine
anakinra
author_facet Riccardo Papa
Federica Penco
Stefano Volpi
Diana Sutera
Roberta Caorsi
Marco Gattorno
author_sort Riccardo Papa
title Syndrome of Undifferentiated Recurrent Fever (SURF): An Emerging Group of Autoinflammatory Recurrent Fevers
title_short Syndrome of Undifferentiated Recurrent Fever (SURF): An Emerging Group of Autoinflammatory Recurrent Fevers
title_full Syndrome of Undifferentiated Recurrent Fever (SURF): An Emerging Group of Autoinflammatory Recurrent Fevers
title_fullStr Syndrome of Undifferentiated Recurrent Fever (SURF): An Emerging Group of Autoinflammatory Recurrent Fevers
title_full_unstemmed Syndrome of Undifferentiated Recurrent Fever (SURF): An Emerging Group of Autoinflammatory Recurrent Fevers
title_sort syndrome of undifferentiated recurrent fever (surf): an emerging group of autoinflammatory recurrent fevers
publisher MDPI AG
series Journal of Clinical Medicine
issn 2077-0383
publishDate 2021-05-01
description Syndrome of undifferentiated recurrent fever (SURF) is a heterogeneous group of autoinflammatory diseases (AID) characterized by self-limiting episodes of systemic inflammation without a confirmed molecular diagnosis, not fulfilling the criteria for periodic fever, aphthous stomatitis, pharyngitis and adenopathy (PFAPA) syndrome. In this review, we focused on the studies enrolling patients suspected of AID and genotyped them with next generation sequencing technologies in order to describe the clinical manifestations and treatment response of published cohorts of patients with SURF. We also propose a preliminary set of indications for the clinical suspicion of SURF that could help in everyday clinical practice.
topic autoinflammatory diseases
NGS
SURF
FMF
colchicine
anakinra
url https://www.mdpi.com/2077-0383/10/9/1963
work_keys_str_mv AT riccardopapa syndromeofundifferentiatedrecurrentfeversurfanemerginggroupofautoinflammatoryrecurrentfevers
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AT dianasutera syndromeofundifferentiatedrecurrentfeversurfanemerginggroupofautoinflammatoryrecurrentfevers
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