Structural Diversity and Biological Activities of Cyclic Depsipeptides from Fungi
Cyclic depsipeptides (CDPs) are cyclopeptides in which amide groups are replaced by corresponding lactone bonds due to the presence of a hydroxylated carboxylic acid in the peptide structure. These peptides sometimes display additional chemical modifications, including unusual amino acid residues in...
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doaj-861d2a7f9c8e4fc9bcd2fba5afe855192020-11-24T23:07:18ZengMDPI AGMolecules1420-30492018-01-0123116910.3390/molecules23010169molecules23010169Structural Diversity and Biological Activities of Cyclic Depsipeptides from FungiXiaohan Wang0Xiao Gong1Peng Li2Daowan Lai3Ligang Zhou4Department of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing 100193, ChinaDepartment of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing 100193, ChinaDepartment of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing 100193, ChinaDepartment of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing 100193, ChinaDepartment of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing 100193, ChinaCyclic depsipeptides (CDPs) are cyclopeptides in which amide groups are replaced by corresponding lactone bonds due to the presence of a hydroxylated carboxylic acid in the peptide structure. These peptides sometimes display additional chemical modifications, including unusual amino acid residues in their structures. This review highlights the occurrence, structures and biological activities of the fungal CDPs reported until October 2017. About 352 fungal CDPs belonging to the groups of cyclic tri-, tetra-, penta-, hexa-, hepta-, octa-, nona-, deca-, and tridecadepsipeptides have been isolated from fungi. These metabolites are mainly reported from the genera Acremonium, Alternaria, Aspergillus, Beauveria, Fusarium, Isaria, Metarhizium, Penicillium, and Rosellina. They are known to exhibit various biological activities such as cytotoxic, phytotoxic, antimicrobial, antiviral, anthelmintic, insecticidal, antimalarial, antitumoral and enzyme-inhibitory activities. Some CDPs (i.e., PF1022A, enniatins and destruxins) have been applied as pharmaceuticals and agrochemicals.http://www.mdpi.com/1420-3049/23/1/169cyclodepsipeptidesfungibiological activitiesoccurrenceapplications |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiaohan Wang Xiao Gong Peng Li Daowan Lai Ligang Zhou |
spellingShingle |
Xiaohan Wang Xiao Gong Peng Li Daowan Lai Ligang Zhou Structural Diversity and Biological Activities of Cyclic Depsipeptides from Fungi Molecules cyclodepsipeptides fungi biological activities occurrence applications |
author_facet |
Xiaohan Wang Xiao Gong Peng Li Daowan Lai Ligang Zhou |
author_sort |
Xiaohan Wang |
title |
Structural Diversity and Biological Activities of Cyclic Depsipeptides from Fungi |
title_short |
Structural Diversity and Biological Activities of Cyclic Depsipeptides from Fungi |
title_full |
Structural Diversity and Biological Activities of Cyclic Depsipeptides from Fungi |
title_fullStr |
Structural Diversity and Biological Activities of Cyclic Depsipeptides from Fungi |
title_full_unstemmed |
Structural Diversity and Biological Activities of Cyclic Depsipeptides from Fungi |
title_sort |
structural diversity and biological activities of cyclic depsipeptides from fungi |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2018-01-01 |
description |
Cyclic depsipeptides (CDPs) are cyclopeptides in which amide groups are replaced by corresponding lactone bonds due to the presence of a hydroxylated carboxylic acid in the peptide structure. These peptides sometimes display additional chemical modifications, including unusual amino acid residues in their structures. This review highlights the occurrence, structures and biological activities of the fungal CDPs reported until October 2017. About 352 fungal CDPs belonging to the groups of cyclic tri-, tetra-, penta-, hexa-, hepta-, octa-, nona-, deca-, and tridecadepsipeptides have been isolated from fungi. These metabolites are mainly reported from the genera Acremonium, Alternaria, Aspergillus, Beauveria, Fusarium, Isaria, Metarhizium, Penicillium, and Rosellina. They are known to exhibit various biological activities such as cytotoxic, phytotoxic, antimicrobial, antiviral, anthelmintic, insecticidal, antimalarial, antitumoral and enzyme-inhibitory activities. Some CDPs (i.e., PF1022A, enniatins and destruxins) have been applied as pharmaceuticals and agrochemicals. |
topic |
cyclodepsipeptides fungi biological activities occurrence applications |
url |
http://www.mdpi.com/1420-3049/23/1/169 |
work_keys_str_mv |
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