Vitamin D metabolites are lower with active Crohn’s disease and spontaneously recover with development of remission
Background: Vitamin D deficiency is associated with active Crohn’s disease (CD). However, it remains unclear if lower 25-hydroxyvitamin D [25(OH)D] concentration is the cause, or consequence, of intestinal inflammation. Existing literature has focused on circulating 25(OH)D rather than the active me...
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Series: | Therapeutic Advances in Gastroenterology |
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doaj-86308fa9220a4d4cb73728138e49cfbc2020-11-25T03:46:03ZengSAGE PublishingTherapeutic Advances in Gastroenterology1756-28482019-07-011210.1177/1756284819865144Vitamin D metabolites are lower with active Crohn’s disease and spontaneously recover with development of remissionCraig HaiferIan C. LawranceJacqueline R. CenterMichael W. ClarkePrue H. HartJohn A. EismanRobyn LucasSimon GhalyBackground: Vitamin D deficiency is associated with active Crohn’s disease (CD). However, it remains unclear if lower 25-hydroxyvitamin D [25(OH)D] concentration is the cause, or consequence, of intestinal inflammation. Existing literature has focused on circulating 25(OH)D rather than the active metabolite 1,25(OH) 2 D, or its breakdown product, 24,25(OH) 2 D. We aimed to characterise vitamin D metabolism in a cohort of patients with active and inactive CD. Methods: Fifty-four patients with CD and not on corticosteroids or vitamin D supplements, were enrolled in a 6-month prospective cohort study. Sera were collected on enrolment and at 6 months and tested for 25(OH)D, 1,25(OH) 2 D, 24,25(OH) 2 D using liquid chromatography tandem mass spectroscopy as well as vitamin-D-binding protein. Results: There were no differences in 25(OH)D or 1,25(OH) 2 D levels between participants with active versus inactive disease. Levels of 24,25(OH) 2 D were significantly lower in those with active compared with inactive disease (mean 3.9 versus 6.0 µmol/l; p = 0.007) and therefore the ratio of 25(OH)D:24,25(OH) 2 D was higher (mean 17.3 versus 11.1; p = 0.001). In those patients with active disease who achieved remission, there was a mean increase in 25(OH)D of 32.3 nmol/l (i.e. to a level in the sufficient range) and 24,25(OH) 2 D of 2.1 µmol/l. These increases were not seen in patients with persistently active or inactive disease. Conclusion: Levels of 24,25(OH) 2 D, but not 25(OH)D, were lower in patients with active CD, and spontaneously increased with resolution of underlying inflammation. The utility of 24,25(OH) 2 D as a biomarker of disease activity and vitamin D status in CD warrants further exploration.https://doi.org/10.1177/1756284819865144 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Craig Haifer Ian C. Lawrance Jacqueline R. Center Michael W. Clarke Prue H. Hart John A. Eisman Robyn Lucas Simon Ghaly |
spellingShingle |
Craig Haifer Ian C. Lawrance Jacqueline R. Center Michael W. Clarke Prue H. Hart John A. Eisman Robyn Lucas Simon Ghaly Vitamin D metabolites are lower with active Crohn’s disease and spontaneously recover with development of remission Therapeutic Advances in Gastroenterology |
author_facet |
Craig Haifer Ian C. Lawrance Jacqueline R. Center Michael W. Clarke Prue H. Hart John A. Eisman Robyn Lucas Simon Ghaly |
author_sort |
Craig Haifer |
title |
Vitamin D metabolites are lower with active Crohn’s disease and spontaneously recover with development of remission |
title_short |
Vitamin D metabolites are lower with active Crohn’s disease and spontaneously recover with development of remission |
title_full |
Vitamin D metabolites are lower with active Crohn’s disease and spontaneously recover with development of remission |
title_fullStr |
Vitamin D metabolites are lower with active Crohn’s disease and spontaneously recover with development of remission |
title_full_unstemmed |
Vitamin D metabolites are lower with active Crohn’s disease and spontaneously recover with development of remission |
title_sort |
vitamin d metabolites are lower with active crohn’s disease and spontaneously recover with development of remission |
publisher |
SAGE Publishing |
series |
Therapeutic Advances in Gastroenterology |
issn |
1756-2848 |
publishDate |
2019-07-01 |
description |
Background: Vitamin D deficiency is associated with active Crohn’s disease (CD). However, it remains unclear if lower 25-hydroxyvitamin D [25(OH)D] concentration is the cause, or consequence, of intestinal inflammation. Existing literature has focused on circulating 25(OH)D rather than the active metabolite 1,25(OH) 2 D, or its breakdown product, 24,25(OH) 2 D. We aimed to characterise vitamin D metabolism in a cohort of patients with active and inactive CD. Methods: Fifty-four patients with CD and not on corticosteroids or vitamin D supplements, were enrolled in a 6-month prospective cohort study. Sera were collected on enrolment and at 6 months and tested for 25(OH)D, 1,25(OH) 2 D, 24,25(OH) 2 D using liquid chromatography tandem mass spectroscopy as well as vitamin-D-binding protein. Results: There were no differences in 25(OH)D or 1,25(OH) 2 D levels between participants with active versus inactive disease. Levels of 24,25(OH) 2 D were significantly lower in those with active compared with inactive disease (mean 3.9 versus 6.0 µmol/l; p = 0.007) and therefore the ratio of 25(OH)D:24,25(OH) 2 D was higher (mean 17.3 versus 11.1; p = 0.001). In those patients with active disease who achieved remission, there was a mean increase in 25(OH)D of 32.3 nmol/l (i.e. to a level in the sufficient range) and 24,25(OH) 2 D of 2.1 µmol/l. These increases were not seen in patients with persistently active or inactive disease. Conclusion: Levels of 24,25(OH) 2 D, but not 25(OH)D, were lower in patients with active CD, and spontaneously increased with resolution of underlying inflammation. The utility of 24,25(OH) 2 D as a biomarker of disease activity and vitamin D status in CD warrants further exploration. |
url |
https://doi.org/10.1177/1756284819865144 |
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