Strategies Towards the Synthesis of N2-Substituted 1,2,3-Triazoles

• Main Authors: RODRIGO OCTÁVIO M.A. DE SOUZA, LEANDRO S. DE MARIZ E MIRANDA
• Format: Article
• Language: English
• Published: Academia Brasileira de Ciências 2019-02-01
• Series: Anais da Academia Brasileira de Ciências
• Subjects: 1,2,3-Triazoles; Heterocycles; Regiosselectivity; arylation
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000200401&lng=en&tlng=en

Abstract The chemistry of 1,2,3-triazoles gained much attention since the discovery of the copper catalyzed Alkyne-azide cycloaddition (CuAAC) reaction which delivers exclusively the 1,4-regioisomer in high yields. On the other hand there is still no universal methodology capable of delivering the N2 substituted regioisomer. The unique properties of these N2-substituted 1,2,3-triazoles have stimulated synthetic efforts on the developments of methodologies capable of delivering it in high yield and selectivity. These efforts are the subject of the presented review.