Portal Dissemination of <i>Fusarium graminearum</i> in a Patient with Acute Lymphoblastic Leukemia and Febrile Neutropenia
We present the case of a man with acute lymphoblastic leukemia and prolonged profound neutropenia, who developed an invasive infection by <i>Fusarium graminearum</i>, acquired via non-cutaneous entry, with gastrointestinal symptoms, sigmoid perforation and liver abscesses due to portal d...
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doaj-863db88c3fe04d31b7e1fa137841d6ea2021-01-02T00:00:03ZengMDPI AGInfectious Disease Reports2036-74492021-01-01132111710.3390/idr13010002Portal Dissemination of <i>Fusarium graminearum</i> in a Patient with Acute Lymphoblastic Leukemia and Febrile NeutropeniaMary Gabriela Uscamayta0Alexandra Martin-Onraet1Karla Espinosa-Bautista2Roberto Herrera-Goepfert3Rigoberto Hernández-Castro4Carolina Perez-Jimenez5Infectious Disease Department, National Institute of Cancer, Mexico City 14080, MexicoInfectious Disease Department, National Institute of Cancer, Mexico City 14080, MexicoHematology Department, National Institute of Cancer, Mexico City 14080, MexicoPathology Department, National Institute of Cancer, Mexico City 14080, MexicoEcology of Pathogen Agents Department, General Hospital Manuel Gea González, Mexico City 14080, MexicoInfectious Disease Department, National Institute of Cancer, Mexico City 14080, MexicoWe present the case of a man with acute lymphoblastic leukemia and prolonged profound neutropenia, who developed an invasive infection by <i>Fusarium graminearum</i>, acquired via non-cutaneous entry, with gastrointestinal symptoms, sigmoid perforation and liver abscesses due to portal dissemination. The etiologic agent was identified using the 18S-ITS1-5.8S-ITS2-28S rRNA sequence gene, from a liver biopsy. The infection was resolved with surgical drainage and antifungal treatment based on voriconazole. As far as we know, there are no previous reports in the literature of cases of human infection due to <i>Fusarium graminearum</i>.https://www.mdpi.com/2036-7449/13/1/2<i>Fusarium graminearum</i>portal disseminationinvasive fungal infectionrRNA sequence genefebrile neutropenia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mary Gabriela Uscamayta Alexandra Martin-Onraet Karla Espinosa-Bautista Roberto Herrera-Goepfert Rigoberto Hernández-Castro Carolina Perez-Jimenez |
spellingShingle |
Mary Gabriela Uscamayta Alexandra Martin-Onraet Karla Espinosa-Bautista Roberto Herrera-Goepfert Rigoberto Hernández-Castro Carolina Perez-Jimenez Portal Dissemination of <i>Fusarium graminearum</i> in a Patient with Acute Lymphoblastic Leukemia and Febrile Neutropenia Infectious Disease Reports <i>Fusarium graminearum</i> portal dissemination invasive fungal infection rRNA sequence gene febrile neutropenia |
author_facet |
Mary Gabriela Uscamayta Alexandra Martin-Onraet Karla Espinosa-Bautista Roberto Herrera-Goepfert Rigoberto Hernández-Castro Carolina Perez-Jimenez |
author_sort |
Mary Gabriela Uscamayta |
title |
Portal Dissemination of <i>Fusarium graminearum</i> in a Patient with Acute Lymphoblastic Leukemia and Febrile Neutropenia |
title_short |
Portal Dissemination of <i>Fusarium graminearum</i> in a Patient with Acute Lymphoblastic Leukemia and Febrile Neutropenia |
title_full |
Portal Dissemination of <i>Fusarium graminearum</i> in a Patient with Acute Lymphoblastic Leukemia and Febrile Neutropenia |
title_fullStr |
Portal Dissemination of <i>Fusarium graminearum</i> in a Patient with Acute Lymphoblastic Leukemia and Febrile Neutropenia |
title_full_unstemmed |
Portal Dissemination of <i>Fusarium graminearum</i> in a Patient with Acute Lymphoblastic Leukemia and Febrile Neutropenia |
title_sort |
portal dissemination of <i>fusarium graminearum</i> in a patient with acute lymphoblastic leukemia and febrile neutropenia |
publisher |
MDPI AG |
series |
Infectious Disease Reports |
issn |
2036-7449 |
publishDate |
2021-01-01 |
description |
We present the case of a man with acute lymphoblastic leukemia and prolonged profound neutropenia, who developed an invasive infection by <i>Fusarium graminearum</i>, acquired via non-cutaneous entry, with gastrointestinal symptoms, sigmoid perforation and liver abscesses due to portal dissemination. The etiologic agent was identified using the 18S-ITS1-5.8S-ITS2-28S rRNA sequence gene, from a liver biopsy. The infection was resolved with surgical drainage and antifungal treatment based on voriconazole. As far as we know, there are no previous reports in the literature of cases of human infection due to <i>Fusarium graminearum</i>. |
topic |
<i>Fusarium graminearum</i> portal dissemination invasive fungal infection rRNA sequence gene febrile neutropenia |
url |
https://www.mdpi.com/2036-7449/13/1/2 |
work_keys_str_mv |
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