IGFBP-5 Promotes Fibrosis via Increasing Its Own Expression and That of Other Pro-fibrotic Mediators

IGFBP-5 Promotes Fibrosis via Increasing Its Own Expression and That of Other Pro-fibrotic Mediators

Pulmonary fibrosis is a hallmark of diseases such as systemic sclerosis (SSc, scleroderma) and idiopathic pulmonary fibrosis (IPF). To date, the therapeutic options for patients with pulmonary fibrosis are limited, and organ transplantation remains the most effective option. Insulin-like growth fact...

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Bibliographic Details
Main Authors: Xinh-Xinh Nguyen, Lutfiyya Muhammad, Paul J. Nietert, Carol Feghali-Bostwick
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Endocrinology
Subjects:
fibrosis
insulin-like growth factor binding protein-5 (IGFBP-5)
systemic sclerosis (SSc)
idiopathic pulmonary fibrosis (IPF)
extracellular matrix (ECM)
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00601/full

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