Effects of organochlorine exposure on male reproductive disorders in an electronic waste area of South China
Several studies suggest that organochlorine exposure can affect male reproductive functions, causing poor semen quality, endocrine disruption, or dysregulation of thyroid hormones. This study uses multiple linear regression (MLR) models to analyze the correlation between male reproductive functions...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-02-01
|
Series: | Environment International |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S016041202032273X |
id |
doaj-86449dfee8d04fceb994be09fecde966 |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bi-gui Lin Cai-rong Chen Xi-chao Chen Jing Qiao Qiu-xia Yan Pan Yang Wan-le Chen Liang-zhong Li Pei-chang Qiu Cheng Ding Dao-jian Huang Yun-jiang Yu |
spellingShingle |
Bi-gui Lin Cai-rong Chen Xi-chao Chen Jing Qiao Qiu-xia Yan Pan Yang Wan-le Chen Liang-zhong Li Pei-chang Qiu Cheng Ding Dao-jian Huang Yun-jiang Yu Effects of organochlorine exposure on male reproductive disorders in an electronic waste area of South China Environment International PCBs p,p'-DDE Semen quality Reproduction hormone Thyroid hormone |
author_facet |
Bi-gui Lin Cai-rong Chen Xi-chao Chen Jing Qiao Qiu-xia Yan Pan Yang Wan-le Chen Liang-zhong Li Pei-chang Qiu Cheng Ding Dao-jian Huang Yun-jiang Yu |
author_sort |
Bi-gui Lin |
title |
Effects of organochlorine exposure on male reproductive disorders in an electronic waste area of South China |
title_short |
Effects of organochlorine exposure on male reproductive disorders in an electronic waste area of South China |
title_full |
Effects of organochlorine exposure on male reproductive disorders in an electronic waste area of South China |
title_fullStr |
Effects of organochlorine exposure on male reproductive disorders in an electronic waste area of South China |
title_full_unstemmed |
Effects of organochlorine exposure on male reproductive disorders in an electronic waste area of South China |
title_sort |
effects of organochlorine exposure on male reproductive disorders in an electronic waste area of south china |
publisher |
Elsevier |
series |
Environment International |
issn |
0160-4120 |
publishDate |
2021-02-01 |
description |
Several studies suggest that organochlorine exposure can affect male reproductive functions, causing poor semen quality, endocrine disruption, or dysregulation of thyroid hormones. This study uses multiple linear regression (MLR) models to analyze the correlation between male reproductive functions and polychlorinated biphenyl (PCBs) congeners or p,p'-DDE levels in serum, semen, and indoor dust samples. Multiple comparisons were all adjusted using the false discovery rate (FDR). The results revealed that the PCB congener levels in seminal plasma were significantly associated with the quality parameters of human semen (i.e., sperm count, morphology, and motility) and thyroid hormones after adjusting for covariates, e.g., associations of the sperm concentration with levels of CB105 (β = −0.323, 95% CI: –0.561, –0.085, p = 0.009), CB44 (β = 0.585, 95% CI: 0.290, 0.880, p < 0.001), and CB66 (β = –0.435, 95% CI: –0.728, –0.143, p = 0.004) in the seminal plasma were observed. Correlations between serum pollutants levels and the semen quality, reproductive hormones, or thyroid hormones were also observed. Moreover, our results demonstrate that the quantification of PCBs in seminal plasma can better describe male reproductive disorders than that in serum or dust. Organochlorine exposure measured in serum or dust, especially in seminal plasma, was associated with semen quality, as well as reproductive and thyroid hormones, thus suggesting that the impacts of persistent pollutants on male reproductive health require further investigation. |
topic |
PCBs p,p'-DDE Semen quality Reproduction hormone Thyroid hormone |
url |
http://www.sciencedirect.com/science/article/pii/S016041202032273X |
work_keys_str_mv |
AT biguilin effectsoforganochlorineexposureonmalereproductivedisordersinanelectronicwasteareaofsouthchina AT cairongchen effectsoforganochlorineexposureonmalereproductivedisordersinanelectronicwasteareaofsouthchina AT xichaochen effectsoforganochlorineexposureonmalereproductivedisordersinanelectronicwasteareaofsouthchina AT jingqiao effectsoforganochlorineexposureonmalereproductivedisordersinanelectronicwasteareaofsouthchina AT qiuxiayan effectsoforganochlorineexposureonmalereproductivedisordersinanelectronicwasteareaofsouthchina AT panyang effectsoforganochlorineexposureonmalereproductivedisordersinanelectronicwasteareaofsouthchina AT wanlechen effectsoforganochlorineexposureonmalereproductivedisordersinanelectronicwasteareaofsouthchina AT liangzhongli effectsoforganochlorineexposureonmalereproductivedisordersinanelectronicwasteareaofsouthchina AT peichangqiu effectsoforganochlorineexposureonmalereproductivedisordersinanelectronicwasteareaofsouthchina AT chengding effectsoforganochlorineexposureonmalereproductivedisordersinanelectronicwasteareaofsouthchina AT daojianhuang effectsoforganochlorineexposureonmalereproductivedisordersinanelectronicwasteareaofsouthchina AT yunjiangyu effectsoforganochlorineexposureonmalereproductivedisordersinanelectronicwasteareaofsouthchina |
_version_ |
1724331412174143488 |
spelling |
doaj-86449dfee8d04fceb994be09fecde9662021-01-20T04:10:28ZengElsevierEnvironment International0160-41202021-02-01147106318Effects of organochlorine exposure on male reproductive disorders in an electronic waste area of South ChinaBi-gui Lin0Cai-rong Chen1Xi-chao Chen2Jing Qiao3Qiu-xia Yan4Pan Yang5Wan-le Chen6Liang-zhong Li7Pei-chang Qiu8Cheng Ding9Dao-jian Huang10Yun-jiang Yu11State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, South China Institute of Environmental Sciences, Ministry of Ecology and Environment, Guangzhou 510655, PR ChinaReproductive Medicine Center, People’s Hospital of Qingyuan, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan 511518, PR ChinaState Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, South China Institute of Environmental Sciences, Ministry of Ecology and Environment, Guangzhou 510655, PR ChinaReproductive Medicine Center, People’s Hospital of Qingyuan, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan 511518, PR ChinaReproductive Medicine Center, People’s Hospital of Qingyuan, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan 511518, PR ChinaGuangdong Key Laboratory of Environmental Pollution and Health, School of the Environment, Jinan University, Guangzhou 510632, PR ChinaReproductive Medicine Center, People’s Hospital of Qingyuan, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan 511518, PR ChinaState Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, South China Institute of Environmental Sciences, Ministry of Ecology and Environment, Guangzhou 510655, PR ChinaReproductive Medicine Center, People’s Hospital of Qingyuan, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan 511518, PR ChinaSchool of Environmental Science and Engineering, Yancheng Institute of Technology, Yancheng 224051, PR ChinaState Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, South China Institute of Environmental Sciences, Ministry of Ecology and Environment, Guangzhou 510655, PR ChinaState Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, South China Institute of Environmental Sciences, Ministry of Ecology and Environment, Guangzhou 510655, PR China; Corresponding author.Several studies suggest that organochlorine exposure can affect male reproductive functions, causing poor semen quality, endocrine disruption, or dysregulation of thyroid hormones. This study uses multiple linear regression (MLR) models to analyze the correlation between male reproductive functions and polychlorinated biphenyl (PCBs) congeners or p,p'-DDE levels in serum, semen, and indoor dust samples. Multiple comparisons were all adjusted using the false discovery rate (FDR). The results revealed that the PCB congener levels in seminal plasma were significantly associated with the quality parameters of human semen (i.e., sperm count, morphology, and motility) and thyroid hormones after adjusting for covariates, e.g., associations of the sperm concentration with levels of CB105 (β = −0.323, 95% CI: –0.561, –0.085, p = 0.009), CB44 (β = 0.585, 95% CI: 0.290, 0.880, p < 0.001), and CB66 (β = –0.435, 95% CI: –0.728, –0.143, p = 0.004) in the seminal plasma were observed. Correlations between serum pollutants levels and the semen quality, reproductive hormones, or thyroid hormones were also observed. Moreover, our results demonstrate that the quantification of PCBs in seminal plasma can better describe male reproductive disorders than that in serum or dust. Organochlorine exposure measured in serum or dust, especially in seminal plasma, was associated with semen quality, as well as reproductive and thyroid hormones, thus suggesting that the impacts of persistent pollutants on male reproductive health require further investigation.http://www.sciencedirect.com/science/article/pii/S016041202032273XPCBsp,p'-DDESemen qualityReproduction hormoneThyroid hormone |