Molecular characterization of Thy1 expressing fear-inhibiting neurons within the basolateral amygdala

Molecular characterization of Thy1 expressing fear-inhibiting neurons within the basolateral amygdala

Activation of Thy-1 expressing neurons in the basolateral amygdala (BLA) has been shown to result in inhibition of fear. Here the authors present a comprehensive workflow to identify genes that are upregulated in this population and can be pharmacologically targeted to enable fear extinction.

Bibliographic Details
Main Authors: Kenneth M. McCullough, Dennis Choi, Jidong Guo, Kelsey Zimmerman, Jordan Walton, Donald G. Rainnie, Kerry J. Ressler
Format: Article
Language:English
Published: Nature Publishing Group 2016-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13149
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spelling doaj-8648cad174914c65a41baa622362e7232021-05-11T10:37:36ZengNature Publishing GroupNature Communications2041-17232016-10-017111310.1038/ncomms13149Molecular characterization of Thy1 expressing fear-inhibiting neurons within the basolateral amygdalaKenneth M. McCullough0Dennis Choi1Jidong Guo2Kelsey Zimmerman3Jordan Walton4Donald G. Rainnie5Kerry J. Ressler6Department of Psychiatry and Behavioral Sciences, Behavioral Neuroscience, Emory UniversityDepartment of Psychiatry and Behavioral Sciences, Behavioral Neuroscience, Emory UniversityDepartment of Psychiatry and Behavioral Sciences, Behavioral Neuroscience, Emory UniversitySchool of Psychology, University of New South WalesDepartment of Psychiatry and Behavioral Sciences, Behavioral Neuroscience, Emory UniversityDepartment of Psychiatry and Behavioral Sciences, Behavioral Neuroscience, Emory UniversityDepartment of Psychiatry and Behavioral Sciences, Behavioral Neuroscience, Emory UniversityActivation of Thy-1 expressing neurons in the basolateral amygdala (BLA) has been shown to result in inhibition of fear. Here the authors present a comprehensive workflow to identify genes that are upregulated in this population and can be pharmacologically targeted to enable fear extinction.https://doi.org/10.1038/ncomms13149
collection DOAJ
language English
format Article
sources DOAJ
author Kenneth M. McCullough
Dennis Choi
Jidong Guo
Kelsey Zimmerman
Jordan Walton
Donald G. Rainnie
Kerry J. Ressler
spellingShingle Kenneth M. McCullough
Dennis Choi
Jidong Guo
Kelsey Zimmerman
Jordan Walton
Donald G. Rainnie
Kerry J. Ressler
Molecular characterization of Thy1 expressing fear-inhibiting neurons within the basolateral amygdala
Nature Communications
author_facet Kenneth M. McCullough
Dennis Choi
Jidong Guo
Kelsey Zimmerman
Jordan Walton
Donald G. Rainnie
Kerry J. Ressler
author_sort Kenneth M. McCullough
title Molecular characterization of Thy1 expressing fear-inhibiting neurons within the basolateral amygdala
title_short Molecular characterization of Thy1 expressing fear-inhibiting neurons within the basolateral amygdala
title_full Molecular characterization of Thy1 expressing fear-inhibiting neurons within the basolateral amygdala
title_fullStr Molecular characterization of Thy1 expressing fear-inhibiting neurons within the basolateral amygdala
title_full_unstemmed Molecular characterization of Thy1 expressing fear-inhibiting neurons within the basolateral amygdala
title_sort molecular characterization of thy1 expressing fear-inhibiting neurons within the basolateral amygdala
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-10-01
description Activation of Thy-1 expressing neurons in the basolateral amygdala (BLA) has been shown to result in inhibition of fear. Here the authors present a comprehensive workflow to identify genes that are upregulated in this population and can be pharmacologically targeted to enable fear extinction.
url https://doi.org/10.1038/ncomms13149
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AT jidongguo molecularcharacterizationofthy1expressingfearinhibitingneuronswithinthebasolateralamygdala
AT kelseyzimmerman molecularcharacterizationofthy1expressingfearinhibitingneuronswithinthebasolateralamygdala
AT jordanwalton molecularcharacterizationofthy1expressingfearinhibitingneuronswithinthebasolateralamygdala
AT donaldgrainnie molecularcharacterizationofthy1expressingfearinhibitingneuronswithinthebasolateralamygdala
AT kerryjressler molecularcharacterizationofthy1expressingfearinhibitingneuronswithinthebasolateralamygdala
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