Heregulin Drives Endocrine Resistance by Altering IL-8 Expression in ER-Positive Breast Cancer

Heregulin Drives Endocrine Resistance by Altering IL-8 Expression in ER-Positive Breast Cancer

Sustained HER2/HER3 signaling due to the overproduction of the HER3 ligand heregulin (HRG) is proposed as a key contributor to endocrine resistance in estrogen receptor-positive (ER+) breast cancer. The molecular mechanisms linking HER2 transactivation by HRG-bound HER3 to the acquisition of a hormo...

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Bibliographic Details
Main Authors: Adriana Papadimitropoulou, Luciano Vellon, Ella Atlas, Travis Vander Steen, Elisabet Cuyàs, Sara Verdura, Ingrid Espinoza, Javier A. Menendez, Ruth Lupu
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
cytokines
IL-8
tamoxifen
autocrine
luminal
Online Access:https://www.mdpi.com/1422-0067/21/20/7737

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