Indeterminate Cell Histiocytosis in Association with Acute Myeloid Leukemia
Indeterminate cell histiocytosis (ICH) is a rare proliferative disorder, in which the predominant cells share morphologic and immunophenotypic features from both Langerhans and non-Langerhans cell histiocytosis. We describe a 62-year-old man presenting a 2-month history of firm nodular lesions on th...
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doaj-864c2ccc413145c6b4f4bc308b2904002020-11-24T23:02:36ZengHindawi LimitedDermatology Research and Practice1687-61051687-61132010-01-01201010.1155/2010/569345569345Indeterminate Cell Histiocytosis in Association with Acute Myeloid LeukemiaFilipa Ventura0Teresa Pereira1Maria da Luz Duarte2Herlander Marques3Fernando Pardal4Celeste Brito5Dermatology and Venereology Department, Braga Hospital, Apartado 2242, 4701-965 Braga, PortugalDermatology and Venereology Department, Braga Hospital, Apartado 2242, 4701-965 Braga, PortugalDermatology and Venereology Department, Braga Hospital, Apartado 2242, 4701-965 Braga, PortugalOncology Department, Braga Hospital, 4701-965 Braga, PortugalPathology Department, Braga Hospital, 4701-965 Braga, PortugalDermatology and Venereology Department, Braga Hospital, Apartado 2242, 4701-965 Braga, PortugalIndeterminate cell histiocytosis (ICH) is a rare proliferative disorder, in which the predominant cells share morphologic and immunophenotypic features from both Langerhans and non-Langerhans cell histiocytosis. We describe a 62-year-old man presenting a 2-month history of firm nodular lesions on the upper lip. Histopathology, immunohistochemical, and ultrastructural analysis showed typical findings of ICH. The patient was treated with thalidomide and almost complete regression of the lesions was reached within 7 months. Nevertheless, one month after remission, he developed an acute myeloid leukemia of the subtype monocytic leukemia (M5). The patient's condition rapidly worsened and he died due to a respiratory failure four weeks later. We present this case because apart of being rare it joins the effectiveness of thalidomide and the association with an acute monocytic leukemia. A review of the literature is made.http://dx.doi.org/10.1155/2010/569345 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Filipa Ventura Teresa Pereira Maria da Luz Duarte Herlander Marques Fernando Pardal Celeste Brito |
spellingShingle |
Filipa Ventura Teresa Pereira Maria da Luz Duarte Herlander Marques Fernando Pardal Celeste Brito Indeterminate Cell Histiocytosis in Association with Acute Myeloid Leukemia Dermatology Research and Practice |
author_facet |
Filipa Ventura Teresa Pereira Maria da Luz Duarte Herlander Marques Fernando Pardal Celeste Brito |
author_sort |
Filipa Ventura |
title |
Indeterminate Cell Histiocytosis in Association with Acute Myeloid Leukemia |
title_short |
Indeterminate Cell Histiocytosis in Association with Acute Myeloid Leukemia |
title_full |
Indeterminate Cell Histiocytosis in Association with Acute Myeloid Leukemia |
title_fullStr |
Indeterminate Cell Histiocytosis in Association with Acute Myeloid Leukemia |
title_full_unstemmed |
Indeterminate Cell Histiocytosis in Association with Acute Myeloid Leukemia |
title_sort |
indeterminate cell histiocytosis in association with acute myeloid leukemia |
publisher |
Hindawi Limited |
series |
Dermatology Research and Practice |
issn |
1687-6105 1687-6113 |
publishDate |
2010-01-01 |
description |
Indeterminate cell histiocytosis (ICH) is a rare proliferative disorder, in which the predominant cells share morphologic and immunophenotypic features from both Langerhans and non-Langerhans cell histiocytosis.
We describe a 62-year-old man presenting a 2-month history of firm nodular lesions on the upper lip. Histopathology, immunohistochemical, and ultrastructural analysis showed typical findings of ICH. The patient was treated with thalidomide and almost complete regression of the lesions was reached within 7 months. Nevertheless, one month after remission, he developed an acute myeloid leukemia of the subtype monocytic leukemia (M5). The patient's condition rapidly worsened and he died due to a respiratory failure four weeks later. We present this case because apart of being rare it joins the effectiveness of thalidomide and the association with an acute monocytic leukemia. A review of the literature is made. |
url |
http://dx.doi.org/10.1155/2010/569345 |
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