Clinicopathologic Features and Risk Factors of Proteinuria in Transplant Glomerulopathy
Background: Transplant glomerulopathy (TG) is one of the main causes of post-transplant proteinuria (PU). The features and possible risk factors for proteinuria in TG patients are uncertain.Methods: We investigated all patients who had biopsy-proven TG from 2000 to 2018 in our center. The clinical a...
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doaj-864d814054d548e089a122b359a8b3f22021-07-02T05:20:01ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-07-01810.3389/fmed.2021.666319666319Clinicopathologic Features and Risk Factors of Proteinuria in Transplant GlomerulopathyQiang Zhang0Qiang Zhang1Klemens Budde2Danilo Schmidt3Fabian Halleck4Michael Duerr5Marcel G. Naik6Manuel Mayrdorfer7Wiebke Duettmann8Frederick Klauschen9Birgit Rudolph10Kaiyin Wu11Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, GermanyDepartment of Organ Transplant, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, GermanyDepartment of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, GermanyDepartment of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, GermanyDepartment of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, GermanyDepartment of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, GermanyDepartment of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, GermanyDepartment of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, GermanyDepartment of Pathology, Charité-Universitätsmedizin Berlin, Berlin, GermanyDepartment of Pathology, Charité-Universitätsmedizin Berlin, Berlin, GermanyDepartment of Pathology, Charité-Universitätsmedizin Berlin, Berlin, GermanyBackground: Transplant glomerulopathy (TG) is one of the main causes of post-transplant proteinuria (PU). The features and possible risk factors for proteinuria in TG patients are uncertain.Methods: We investigated all patients who had biopsy-proven TG from 2000 to 2018 in our center. The clinical and histological data were compared between two groups with or without PU (cut-off = 0.3 g/day). Spearman correlation analysis was used to evaluate the relationship between PU and pathological changes. The risk factors for PU in TG patients were determined by multivariable logistic regression analysis.Results: One hundred and twenty-five (75.76%) of all enrolled 165 TG patients had proteinuria ≥0.3 g/day at the time of biopsy. TG patients' PU level was significantly correlated with Banff lesion score cg (ρ = 0.247, P = 0.003), and mm (ρ = 0.257, P = 0.012). Systolic blood pressure ≥140 mmHg (OR 2.72, 95% CI 1.04–7.10, P = 0.041), diastolic blood pressure ≥90 mmHg (OR 4.84, 95% CI 1.39–16.82, P = 0.013), peak PRA ≥5% (OR 6.47, 95% CI 1.67–25.01, P = 0.007), positive C4d staining (OR 4.55, 95% CI 1.29–16.11, 0.019), tacrolimus-based regimen (OR 3.5, 95% CI 1.28–9.54, P = 0.014), and calcium channel blocker usage (OR 4.38, 95% CI 1.59–12.09, P = 0.004) were independent risk factors for PU.Conclusions: Proteinuria is common in TG patients. systolic blood pressure ≥140 mmHg, diastolic blood pressure ≥90 mmHg, peak PRA ≥5%, positive C4d staining, tacrolimus-based regimen, and calcium channel blocker usage are associated with proteinuria in TG patients.https://www.frontiersin.org/articles/10.3389/fmed.2021.666319/fullblood pressuregraft functionkidney transplantationproteinuriarenal biopsy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qiang Zhang Qiang Zhang Klemens Budde Danilo Schmidt Fabian Halleck Michael Duerr Marcel G. Naik Manuel Mayrdorfer Wiebke Duettmann Frederick Klauschen Birgit Rudolph Kaiyin Wu |
spellingShingle |
Qiang Zhang Qiang Zhang Klemens Budde Danilo Schmidt Fabian Halleck Michael Duerr Marcel G. Naik Manuel Mayrdorfer Wiebke Duettmann Frederick Klauschen Birgit Rudolph Kaiyin Wu Clinicopathologic Features and Risk Factors of Proteinuria in Transplant Glomerulopathy Frontiers in Medicine blood pressure graft function kidney transplantation proteinuria renal biopsy |
author_facet |
Qiang Zhang Qiang Zhang Klemens Budde Danilo Schmidt Fabian Halleck Michael Duerr Marcel G. Naik Manuel Mayrdorfer Wiebke Duettmann Frederick Klauschen Birgit Rudolph Kaiyin Wu |
author_sort |
Qiang Zhang |
title |
Clinicopathologic Features and Risk Factors of Proteinuria in Transplant Glomerulopathy |
title_short |
Clinicopathologic Features and Risk Factors of Proteinuria in Transplant Glomerulopathy |
title_full |
Clinicopathologic Features and Risk Factors of Proteinuria in Transplant Glomerulopathy |
title_fullStr |
Clinicopathologic Features and Risk Factors of Proteinuria in Transplant Glomerulopathy |
title_full_unstemmed |
Clinicopathologic Features and Risk Factors of Proteinuria in Transplant Glomerulopathy |
title_sort |
clinicopathologic features and risk factors of proteinuria in transplant glomerulopathy |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Medicine |
issn |
2296-858X |
publishDate |
2021-07-01 |
description |
Background: Transplant glomerulopathy (TG) is one of the main causes of post-transplant proteinuria (PU). The features and possible risk factors for proteinuria in TG patients are uncertain.Methods: We investigated all patients who had biopsy-proven TG from 2000 to 2018 in our center. The clinical and histological data were compared between two groups with or without PU (cut-off = 0.3 g/day). Spearman correlation analysis was used to evaluate the relationship between PU and pathological changes. The risk factors for PU in TG patients were determined by multivariable logistic regression analysis.Results: One hundred and twenty-five (75.76%) of all enrolled 165 TG patients had proteinuria ≥0.3 g/day at the time of biopsy. TG patients' PU level was significantly correlated with Banff lesion score cg (ρ = 0.247, P = 0.003), and mm (ρ = 0.257, P = 0.012). Systolic blood pressure ≥140 mmHg (OR 2.72, 95% CI 1.04–7.10, P = 0.041), diastolic blood pressure ≥90 mmHg (OR 4.84, 95% CI 1.39–16.82, P = 0.013), peak PRA ≥5% (OR 6.47, 95% CI 1.67–25.01, P = 0.007), positive C4d staining (OR 4.55, 95% CI 1.29–16.11, 0.019), tacrolimus-based regimen (OR 3.5, 95% CI 1.28–9.54, P = 0.014), and calcium channel blocker usage (OR 4.38, 95% CI 1.59–12.09, P = 0.004) were independent risk factors for PU.Conclusions: Proteinuria is common in TG patients. systolic blood pressure ≥140 mmHg, diastolic blood pressure ≥90 mmHg, peak PRA ≥5%, positive C4d staining, tacrolimus-based regimen, and calcium channel blocker usage are associated with proteinuria in TG patients. |
topic |
blood pressure graft function kidney transplantation proteinuria renal biopsy |
url |
https://www.frontiersin.org/articles/10.3389/fmed.2021.666319/full |
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