Association of a genetic variation in a miR-191 binding site in MDM4 with risk of esophageal squamous cell carcinoma.

Association of a genetic variation in a miR-191 binding site in MDM4 with risk of esophageal squamous cell carcinoma.

As an oncoprotein, MDM4 plays a key part in P53 tumor suppressor pathway through negatively regulating P53 function. It has been reported that an rs4245739 A>C polymorphism locating in the MDM4 3'-untranslated region creates a miR-191 target site and results in decreased MDM4 expression. The...

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Bibliographic Details
Main Authors: Liqing Zhou, Xiaojiao Zhang, Ziqiang Li, Changchun Zhou, Meng Li, Xiaohu Tang, Chao Lu, Helou Li, Qipeng Yuan, Ming Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3665831?pdf=render

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