Propofol inhibited autophagy through Ca2+/CaMKKβ/AMPK/mTOR pathway in OGD/R-induced neuron injury

Propofol inhibited autophagy through Ca2+/CaMKKβ/AMPK/mTOR pathway in OGD/R-induced neuron injury

Abstract Background The neuroprotective role of propofol (PPF) in cerebral ischemia-reperfusion (I/R) has recently been highlighted. This study aimed to explore whether the neuroprotective mechanisms of PPF were linked to its regulation of Ca2+/CaMKKβ (calmodulin-dependent protein kinase kinase β)/A...

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Bibliographic Details
Main Authors: Bei Sun, Hao Ou, Fei Ren, Ye Huan, Tao Zhong, Min Gao, Hongwei Cai
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Molecular Medicine
Subjects:
Propofol
Oxygen-glucose deprivation and re-oxygenation
Autophagy
Ca2+/CaMKKβ/AMPK/mTOR
Online Access:http://link.springer.com/article/10.1186/s10020-018-0054-1

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