Lanthanide DO3A-Complexes Bearing Peptide Substrates: The Effect of Peptidic Side Chains on Metal Coordination and Relaxivity

Lanthanide DO3A-Complexes Bearing Peptide Substrates: The Effect of Peptidic Side Chains on Metal Coordination and Relaxivity

Two DO3A-type ligands conjugated to substrates of urokinase (L3) and caspase-3 (L4) via a propyl-amide linker were synthesized and their lanthanide(III) (Ln<sup>3+</sup>) complexes studied. A model compound without peptide substrate (L2) and an amine derivative ligand mimicking the state...

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Bibliographic Details
Main Authors: Sophie Laine, Jean-François Morfin, Mathieu Galibert, Vincent Aucagne, Célia S. Bonnet, Éva Tóth
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Molecules
Subjects:
lanthanide
MRI contrast agents
peptide
enzymatic detection
Online Access:https://www.mdpi.com/1420-3049/26/8/2176

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