Rapidly Neutralizable and Highly Anticoagulant Thrombin-Binding DNA Aptamer Discovered by MACE SELEX

Rapidly Neutralizable and Highly Anticoagulant Thrombin-Binding DNA Aptamer Discovered by MACE SELEX

We present a rapidly neutralizable and highly anticoagulant thrombin-binding aptamer with a short toehold sequence, originally discovered by systematic evolution of ligands by exponential enrichment (SELEX) with microbead-assisted capillary electrophoresis (MACE). MACE is a novel CE-partitioning met...

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Bibliographic Details
Main Authors: Koji Wakui, Toru Yoshitomi, Akane Yamaguchi, Maho Tsuchida, Shingo Saito, Masami Shibukawa, Hitoshi Furusho, Keitaro Yoshimoto
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Molecular Therapy: Nucleic Acids
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253119300605

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http://www.sciencedirect.com/science/article/pii/S2162253119300605

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