Antimicrobial resistance in clinical Escherichia coli isolates from poultry and livestock, China.
Poultry and livestock are the most important reservoirs for pathogenic Escherichia coli and use of antimicrobials in animal farming is considered the most important factor promoting the emergence, selection and dissemination of antimicrobial-resistant microorganisms. The aim of our study was to inve...
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doaj-867bad9c56264603a6e19696371f155d2020-11-24T20:50:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01129e018532610.1371/journal.pone.0185326Antimicrobial resistance in clinical Escherichia coli isolates from poultry and livestock, China.Afrah Kamal YassinJiansen GongPatrick KellyGuangwu LuLuca GuardabassiLanjing WeiXiangan HanHaixiang QiuStuart PriceDarong ChengChengming WangPoultry and livestock are the most important reservoirs for pathogenic Escherichia coli and use of antimicrobials in animal farming is considered the most important factor promoting the emergence, selection and dissemination of antimicrobial-resistant microorganisms. The aim of our study was to investigate antimicrobial resistance in E. coli isolated from food animals in Jiangsu, China. The disc diffusion method was used to determine susceptibility to 18 antimicrobial agents in 862 clinical isolates collected from chickens, ducks, pigs, and cows between 2004 and 2012. Overall, 94% of the isolates showed resistance to at least one drug with 83% being resistance to at least three different classes of antimicrobials. The isolates from the different species were most commonly resistant to tetracycline, nalidixic acid, sulfamethoxazole, trimethoprim/sulfamethoxazole and ampicillin, and showed increasing resistance to amikacin, aztreonam, ceftazidime, cefotaxime, chloramphenicol, ciprofloxacin. They were least resistant to amoxicillin/clavulanic acid (3.4%) and ertapenem (0.2%). MDR was most common in isolates from ducks (44/44, 100%), followed by chickens (568/644, 88.2%), pigs (93/113, 82.3%) and cows (13/61, 21.3%). Our finding that clinical E. coli isolates from poultry and livestock are commonly resistant to multiple antibiotics should alert public health and veterinary authorities to limit and rationalize antimicrobial use in China.http://europepmc.org/articles/PMC5608385?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Afrah Kamal Yassin Jiansen Gong Patrick Kelly Guangwu Lu Luca Guardabassi Lanjing Wei Xiangan Han Haixiang Qiu Stuart Price Darong Cheng Chengming Wang |
spellingShingle |
Afrah Kamal Yassin Jiansen Gong Patrick Kelly Guangwu Lu Luca Guardabassi Lanjing Wei Xiangan Han Haixiang Qiu Stuart Price Darong Cheng Chengming Wang Antimicrobial resistance in clinical Escherichia coli isolates from poultry and livestock, China. PLoS ONE |
author_facet |
Afrah Kamal Yassin Jiansen Gong Patrick Kelly Guangwu Lu Luca Guardabassi Lanjing Wei Xiangan Han Haixiang Qiu Stuart Price Darong Cheng Chengming Wang |
author_sort |
Afrah Kamal Yassin |
title |
Antimicrobial resistance in clinical Escherichia coli isolates from poultry and livestock, China. |
title_short |
Antimicrobial resistance in clinical Escherichia coli isolates from poultry and livestock, China. |
title_full |
Antimicrobial resistance in clinical Escherichia coli isolates from poultry and livestock, China. |
title_fullStr |
Antimicrobial resistance in clinical Escherichia coli isolates from poultry and livestock, China. |
title_full_unstemmed |
Antimicrobial resistance in clinical Escherichia coli isolates from poultry and livestock, China. |
title_sort |
antimicrobial resistance in clinical escherichia coli isolates from poultry and livestock, china. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2017-01-01 |
description |
Poultry and livestock are the most important reservoirs for pathogenic Escherichia coli and use of antimicrobials in animal farming is considered the most important factor promoting the emergence, selection and dissemination of antimicrobial-resistant microorganisms. The aim of our study was to investigate antimicrobial resistance in E. coli isolated from food animals in Jiangsu, China. The disc diffusion method was used to determine susceptibility to 18 antimicrobial agents in 862 clinical isolates collected from chickens, ducks, pigs, and cows between 2004 and 2012. Overall, 94% of the isolates showed resistance to at least one drug with 83% being resistance to at least three different classes of antimicrobials. The isolates from the different species were most commonly resistant to tetracycline, nalidixic acid, sulfamethoxazole, trimethoprim/sulfamethoxazole and ampicillin, and showed increasing resistance to amikacin, aztreonam, ceftazidime, cefotaxime, chloramphenicol, ciprofloxacin. They were least resistant to amoxicillin/clavulanic acid (3.4%) and ertapenem (0.2%). MDR was most common in isolates from ducks (44/44, 100%), followed by chickens (568/644, 88.2%), pigs (93/113, 82.3%) and cows (13/61, 21.3%). Our finding that clinical E. coli isolates from poultry and livestock are commonly resistant to multiple antibiotics should alert public health and veterinary authorities to limit and rationalize antimicrobial use in China. |
url |
http://europepmc.org/articles/PMC5608385?pdf=render |
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