The Role of Cell Division Autoantigen 1 (CDA1) in Renal Fibrosis of Diabetic Nephropathy
The common kidney disease diabetic nephropathy (DN) accounts for significant morbidity and mortality in patients with diabetes, and its effective diagnosis in incipient stages is still lacking. Renal fibrosis is the main pathological feature of DN. Cell division autoantigen 1 (CDA1), a phosphorylate...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2021-01-01
|
Series: | BioMed Research International |
Online Access: | http://dx.doi.org/10.1155/2021/6651075 |
id |
doaj-86800a48ce0147c9a09bcc35f2906274 |
---|---|
record_format |
Article |
spelling |
doaj-86800a48ce0147c9a09bcc35f29062742021-05-10T00:26:52ZengHindawi LimitedBioMed Research International2314-61412021-01-01202110.1155/2021/6651075The Role of Cell Division Autoantigen 1 (CDA1) in Renal Fibrosis of Diabetic NephropathyLinLin Chen0Jiao Wu1Bin Hu2Changbai Liu3Hu Wang4Affiliated Ren He Hospital of China Three Gorges UniversityAffiliated Ren He Hospital of China Three Gorges UniversityAffiliated Ren He Hospital of China Three Gorges UniversityMedical SchoolMedical SchoolThe common kidney disease diabetic nephropathy (DN) accounts for significant morbidity and mortality in patients with diabetes, and its effective diagnosis in incipient stages is still lacking. Renal fibrosis is the main pathological feature of DN. Cell division autoantigen 1 (CDA1), a phosphorylated protein encoded by TSPYL2 on the X chromosome, plays a fibrogenic role by modulating the transforming growth factor-β (TGF-β) signaling, but the exact mechanism remains unclear. TGF-β signaling has been recognized as the key factor in promoting the development and progression of DN. At present, strict control of blood sugar and blood pressure can significantly lower the development and progression of DN in the early stages, and many studies have shown that blocking TGF-β signaling can delay the progress of DN. However, TGF-β is a multifunctional cytokine. Its direct intervention may result in increased side effects. Therefore, the targeted intervention of CDA1 not only can block the TGF-β signaling pathway but also can reduce these side effects. In this article, we review the main physiological roles of CDA1, with particular attention to its effect and potential mechanism in the renal fibrosis of DN.http://dx.doi.org/10.1155/2021/6651075 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
LinLin Chen Jiao Wu Bin Hu Changbai Liu Hu Wang |
spellingShingle |
LinLin Chen Jiao Wu Bin Hu Changbai Liu Hu Wang The Role of Cell Division Autoantigen 1 (CDA1) in Renal Fibrosis of Diabetic Nephropathy BioMed Research International |
author_facet |
LinLin Chen Jiao Wu Bin Hu Changbai Liu Hu Wang |
author_sort |
LinLin Chen |
title |
The Role of Cell Division Autoantigen 1 (CDA1) in Renal Fibrosis of Diabetic Nephropathy |
title_short |
The Role of Cell Division Autoantigen 1 (CDA1) in Renal Fibrosis of Diabetic Nephropathy |
title_full |
The Role of Cell Division Autoantigen 1 (CDA1) in Renal Fibrosis of Diabetic Nephropathy |
title_fullStr |
The Role of Cell Division Autoantigen 1 (CDA1) in Renal Fibrosis of Diabetic Nephropathy |
title_full_unstemmed |
The Role of Cell Division Autoantigen 1 (CDA1) in Renal Fibrosis of Diabetic Nephropathy |
title_sort |
role of cell division autoantigen 1 (cda1) in renal fibrosis of diabetic nephropathy |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6141 |
publishDate |
2021-01-01 |
description |
The common kidney disease diabetic nephropathy (DN) accounts for significant morbidity and mortality in patients with diabetes, and its effective diagnosis in incipient stages is still lacking. Renal fibrosis is the main pathological feature of DN. Cell division autoantigen 1 (CDA1), a phosphorylated protein encoded by TSPYL2 on the X chromosome, plays a fibrogenic role by modulating the transforming growth factor-β (TGF-β) signaling, but the exact mechanism remains unclear. TGF-β signaling has been recognized as the key factor in promoting the development and progression of DN. At present, strict control of blood sugar and blood pressure can significantly lower the development and progression of DN in the early stages, and many studies have shown that blocking TGF-β signaling can delay the progress of DN. However, TGF-β is a multifunctional cytokine. Its direct intervention may result in increased side effects. Therefore, the targeted intervention of CDA1 not only can block the TGF-β signaling pathway but also can reduce these side effects. In this article, we review the main physiological roles of CDA1, with particular attention to its effect and potential mechanism in the renal fibrosis of DN. |
url |
http://dx.doi.org/10.1155/2021/6651075 |
work_keys_str_mv |
AT linlinchen theroleofcelldivisionautoantigen1cda1inrenalfibrosisofdiabeticnephropathy AT jiaowu theroleofcelldivisionautoantigen1cda1inrenalfibrosisofdiabeticnephropathy AT binhu theroleofcelldivisionautoantigen1cda1inrenalfibrosisofdiabeticnephropathy AT changbailiu theroleofcelldivisionautoantigen1cda1inrenalfibrosisofdiabeticnephropathy AT huwang theroleofcelldivisionautoantigen1cda1inrenalfibrosisofdiabeticnephropathy AT linlinchen roleofcelldivisionautoantigen1cda1inrenalfibrosisofdiabeticnephropathy AT jiaowu roleofcelldivisionautoantigen1cda1inrenalfibrosisofdiabeticnephropathy AT binhu roleofcelldivisionautoantigen1cda1inrenalfibrosisofdiabeticnephropathy AT changbailiu roleofcelldivisionautoantigen1cda1inrenalfibrosisofdiabeticnephropathy AT huwang roleofcelldivisionautoantigen1cda1inrenalfibrosisofdiabeticnephropathy |
_version_ |
1721453836490506240 |