The Biochemical and Genetic Basis for the Biosynthesis of Bioactive Compounds in <i>Hypericum Perforatum</i> L., One of the Largest Medicinal Crops in Europe
<i>Hypericum perforatum</i> L. commonly known as Saint John’s Wort (SJW), is an important medicinal plant that has been used for more than 2000 years. Although <i>H. perforatum</i> produces several bioactive compounds, its importance is mainly linked to two molecules highly r...
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doaj-86809b176bb741a8bf34b3ae4bb279fa2020-11-25T03:38:17ZengMDPI AGGenes2073-44252020-10-01111210121010.3390/genes11101210The Biochemical and Genetic Basis for the Biosynthesis of Bioactive Compounds in <i>Hypericum Perforatum</i> L., One of the Largest Medicinal Crops in EuropeParide Rizzo0Lothar Altschmied1Beena M. Ravindran2Twan Rutten3John C. D’Auria4Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), 06466 Gatersleben, GermanyLeibniz Institute of Plant Genetics and Crop Plant Research (IPK), 06466 Gatersleben, GermanyLeibniz Institute of Plant Genetics and Crop Plant Research (IPK), 06466 Gatersleben, GermanyLeibniz Institute of Plant Genetics and Crop Plant Research (IPK), 06466 Gatersleben, GermanyLeibniz Institute of Plant Genetics and Crop Plant Research (IPK), 06466 Gatersleben, Germany<i>Hypericum perforatum</i> L. commonly known as Saint John’s Wort (SJW), is an important medicinal plant that has been used for more than 2000 years. Although <i>H. perforatum</i> produces several bioactive compounds, its importance is mainly linked to two molecules highly relevant for the pharmaceutical industry: the prenylated phloroglucinol hyperforin and the naphtodianthrone hypericin. The first functions as a natural antidepressant while the second is regarded as a powerful anticancer drug and as a useful compound for the treatment of Alzheimer’s disease. While the antidepressant activity of SJW extracts motivate a multi-billion dollar industry around the world, the scientific interest centers around the biosynthetic pathways of hyperforin and hypericin and their medical applications. Here, we focus on what is known about these processes and evaluate the possibilities of combining state of the art omics, genome editing, and synthetic biology to unlock applications that would be of great value for the pharmaceutical and medical industries.https://www.mdpi.com/2073-4425/11/10/1210<i>Hypericum perforatum</i>Saint John’s Worthypericinhyperforindark glandspale glands |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Paride Rizzo Lothar Altschmied Beena M. Ravindran Twan Rutten John C. D’Auria |
spellingShingle |
Paride Rizzo Lothar Altschmied Beena M. Ravindran Twan Rutten John C. D’Auria The Biochemical and Genetic Basis for the Biosynthesis of Bioactive Compounds in <i>Hypericum Perforatum</i> L., One of the Largest Medicinal Crops in Europe Genes <i>Hypericum perforatum</i> Saint John’s Wort hypericin hyperforin dark glands pale glands |
author_facet |
Paride Rizzo Lothar Altschmied Beena M. Ravindran Twan Rutten John C. D’Auria |
author_sort |
Paride Rizzo |
title |
The Biochemical and Genetic Basis for the Biosynthesis of Bioactive Compounds in <i>Hypericum Perforatum</i> L., One of the Largest Medicinal Crops in Europe |
title_short |
The Biochemical and Genetic Basis for the Biosynthesis of Bioactive Compounds in <i>Hypericum Perforatum</i> L., One of the Largest Medicinal Crops in Europe |
title_full |
The Biochemical and Genetic Basis for the Biosynthesis of Bioactive Compounds in <i>Hypericum Perforatum</i> L., One of the Largest Medicinal Crops in Europe |
title_fullStr |
The Biochemical and Genetic Basis for the Biosynthesis of Bioactive Compounds in <i>Hypericum Perforatum</i> L., One of the Largest Medicinal Crops in Europe |
title_full_unstemmed |
The Biochemical and Genetic Basis for the Biosynthesis of Bioactive Compounds in <i>Hypericum Perforatum</i> L., One of the Largest Medicinal Crops in Europe |
title_sort |
biochemical and genetic basis for the biosynthesis of bioactive compounds in <i>hypericum perforatum</i> l., one of the largest medicinal crops in europe |
publisher |
MDPI AG |
series |
Genes |
issn |
2073-4425 |
publishDate |
2020-10-01 |
description |
<i>Hypericum perforatum</i> L. commonly known as Saint John’s Wort (SJW), is an important medicinal plant that has been used for more than 2000 years. Although <i>H. perforatum</i> produces several bioactive compounds, its importance is mainly linked to two molecules highly relevant for the pharmaceutical industry: the prenylated phloroglucinol hyperforin and the naphtodianthrone hypericin. The first functions as a natural antidepressant while the second is regarded as a powerful anticancer drug and as a useful compound for the treatment of Alzheimer’s disease. While the antidepressant activity of SJW extracts motivate a multi-billion dollar industry around the world, the scientific interest centers around the biosynthetic pathways of hyperforin and hypericin and their medical applications. Here, we focus on what is known about these processes and evaluate the possibilities of combining state of the art omics, genome editing, and synthetic biology to unlock applications that would be of great value for the pharmaceutical and medical industries. |
topic |
<i>Hypericum perforatum</i> Saint John’s Wort hypericin hyperforin dark glands pale glands |
url |
https://www.mdpi.com/2073-4425/11/10/1210 |
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