The Influence of Blood Glucose Meter Resistance Variation on the Performance of a Biosensor with a Gold-Coated Circuit Board
In this study, a novel gold-coated test strip for blood glucose measurement has been designed. Such gold-coated test strip is feasible for mass production to achieve economies of scale. Cyclic voltammetry was applied to test strips to undergo electrochemical reaction under a potential range of ±0.4 ...
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Online Access: | http://dx.doi.org/10.1155/2019/5948182 |
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doaj-868ba3f67bff4de1a31399821cfb47a22020-11-24T23:56:40ZengHindawi LimitedJournal of Sensors1687-725X1687-72682019-01-01201910.1155/2019/59481825948182The Influence of Blood Glucose Meter Resistance Variation on the Performance of a Biosensor with a Gold-Coated Circuit BoardKun-Yong Kim0Ho Chang1Win-Der Lee2Yi-Fan Cai3You-Jia Chen4Graduate Institute of Manufacturing Technology, National Taipei University of Technology, Taipei 10608, TaiwanGraduate Institute of Manufacturing Technology, National Taipei University of Technology, Taipei 10608, TaiwanDepartment of Electrical Engineering, Lee-Ming Institute of technology, Taishan, New Taipei 24305, TaiwanDepartment of Electrical Engineering, Lee-Ming Institute of technology, Taishan, New Taipei 24305, TaiwanDepartment of Electrical Engineering, Lee-Ming Institute of technology, Taishan, New Taipei 24305, TaiwanIn this study, a novel gold-coated test strip for blood glucose measurement has been designed. Such gold-coated test strip is feasible for mass production to achieve economies of scale. Cyclic voltammetry was applied to test strips to undergo electrochemical reaction under a potential range of ±0.4 V. Glucose oxidase (GOD) was added into K3[Fe(CN)6]. When glucose oxidase undergoes electrochemical reaction, the medium, K3[Fe(CN)6], will act as an electron acceptor, causing the electrodes on the test strip to generate a pair of clear anodic and reductive peaks. The maximum of the anodic and reductive peaks can be used as reference to adjust the resistance of the blood glucose meter. The experimental results show that by adjusting the resistance of the blood glucose meter, the accuracy of blood glucose meter reading can be tuned and blood glucose reading can be stabilized. Therefore, when the resistance of the blood glucose meter is at 2.4 KΩ, the standard deviation (STD) and coefficient of variation (CV) of the test strip are lower than those of the test strips measured at resistances of 2.2 KΩ and 2.6 KΩ. It has been proved in this study that adjusting the resistance of the blood glucose meter can optimize the chemical reaction on gold-coated test strips as well as its reading. This method can also be applied to tune the accuracy of readings for test strips coated with other materials.http://dx.doi.org/10.1155/2019/5948182 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kun-Yong Kim Ho Chang Win-Der Lee Yi-Fan Cai You-Jia Chen |
spellingShingle |
Kun-Yong Kim Ho Chang Win-Der Lee Yi-Fan Cai You-Jia Chen The Influence of Blood Glucose Meter Resistance Variation on the Performance of a Biosensor with a Gold-Coated Circuit Board Journal of Sensors |
author_facet |
Kun-Yong Kim Ho Chang Win-Der Lee Yi-Fan Cai You-Jia Chen |
author_sort |
Kun-Yong Kim |
title |
The Influence of Blood Glucose Meter Resistance Variation on the Performance of a Biosensor with a Gold-Coated Circuit Board |
title_short |
The Influence of Blood Glucose Meter Resistance Variation on the Performance of a Biosensor with a Gold-Coated Circuit Board |
title_full |
The Influence of Blood Glucose Meter Resistance Variation on the Performance of a Biosensor with a Gold-Coated Circuit Board |
title_fullStr |
The Influence of Blood Glucose Meter Resistance Variation on the Performance of a Biosensor with a Gold-Coated Circuit Board |
title_full_unstemmed |
The Influence of Blood Glucose Meter Resistance Variation on the Performance of a Biosensor with a Gold-Coated Circuit Board |
title_sort |
influence of blood glucose meter resistance variation on the performance of a biosensor with a gold-coated circuit board |
publisher |
Hindawi Limited |
series |
Journal of Sensors |
issn |
1687-725X 1687-7268 |
publishDate |
2019-01-01 |
description |
In this study, a novel gold-coated test strip for blood glucose measurement has been designed. Such gold-coated test strip is feasible for mass production to achieve economies of scale. Cyclic voltammetry was applied to test strips to undergo electrochemical reaction under a potential range of ±0.4 V. Glucose oxidase (GOD) was added into K3[Fe(CN)6]. When glucose oxidase undergoes electrochemical reaction, the medium, K3[Fe(CN)6], will act as an electron acceptor, causing the electrodes on the test strip to generate a pair of clear anodic and reductive peaks. The maximum of the anodic and reductive peaks can be used as reference to adjust the resistance of the blood glucose meter. The experimental results show that by adjusting the resistance of the blood glucose meter, the accuracy of blood glucose meter reading can be tuned and blood glucose reading can be stabilized. Therefore, when the resistance of the blood glucose meter is at 2.4 KΩ, the standard deviation (STD) and coefficient of variation (CV) of the test strip are lower than those of the test strips measured at resistances of 2.2 KΩ and 2.6 KΩ. It has been proved in this study that adjusting the resistance of the blood glucose meter can optimize the chemical reaction on gold-coated test strips as well as its reading. This method can also be applied to tune the accuracy of readings for test strips coated with other materials. |
url |
http://dx.doi.org/10.1155/2019/5948182 |
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