临床病理学在自身免疫性肝病诊治中的重要性
Liver biopsy plays an important role in the diagnosis of autoimmune liver diseases, particularly in patients without specific clinical manifestations or negative for autoantibodies. The histological features of several autoimmune liver diseases are reviewed. The characteristic features of autoimmune...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Journal of Clinical Hepatology
2014-05-01
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| Series: | Linchuang Gandanbing Zazhi |
| Subjects: | |
| Online Access: | http://www.lcgdbzz.org/qk_content.asp?id=5840&ClassID=42414259 |
| Summary: | Liver biopsy plays an important role in the diagnosis of autoimmune liver diseases, particularly in patients without specific clinical manifestations or negative for autoantibodies. The histological features of several autoimmune liver diseases are reviewed. The characteristic features of autoimmune hepatitis in histology include interface hepatitis with lymphoplasmacytic infiltration, hepatic rosette formation, and emperipolesis, while chronic nonsuppurative destructive cholangitis and epithelioid granuloma are frequently found in primary biliary cirrhosis. Primary sclerosing cholangitis is characterized by onion skin-like periductal fibrosis, while storiform fibrosis with IgG4-positive plasma cell infiltration often indicates IgG4-related sclerosing cholangitis. Enhanced communication between clinicians and pathologists can help improve the diagnosis and treatment of autoimmune liver diseoses. |
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| ISSN: | 1001-5256 1001-5256 |