Crystal structure of the Formin mDia1 in autoinhibited conformation.

Crystal structure of the Formin mDia1 in autoinhibited conformation.

Formin proteins utilize a conserved formin homology 2 (FH2) domain to nucleate new actin filaments. In mammalian diaphanous-related formins (DRFs) the FH2 domain is inhibited through an unknown mechanism by intramolecular binding of the diaphanous autoinhibitory domain (DAD) and the diaphanous inhib...

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Bibliographic Details
Main Authors: Takanori Otomo, Diana R Tomchick, Chinatsu Otomo, Mischa Machius, Michael K Rosen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2948019?pdf=render

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