Orally administered gold nanoparticles protect against colitis by attenuating Toll-like receptor 4- and reactive oxygen/nitrogen species-mediated inflammatory responses but could induce gut dysbiosis in mice

Orally administered gold nanoparticles protect against colitis by attenuating Toll-like receptor 4- and reactive oxygen/nitrogen species-mediated inflammatory responses but could induce gut dysbiosis in mice

Abstract Background Gold nanoparticles (AuNPs) are attracting interest as potential therapeutic agents to treat inflammatory diseases, but their anti-inflammatory mechanism of action is not clear yet. In addition, the effect of orally administered AuNPs on gut microbiota has been overlooked so far....

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Bibliographic Details
Main Authors: Suqin Zhu, Xiumei Jiang, Mary D. Boudreau, Guangxin Feng, Yu Miao, Shiyuan Dong, Haohao Wu, Mingyong Zeng, Jun-Jie Yin
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Journal of Nanobiotechnology
Subjects:
Gold nanoparticles
Inflammatory bowel disease
Gut microbiota
Reactive oxygen/nitrogen species
Toll-like receptors
Online Access:http://link.springer.com/article/10.1186/s12951-018-0415-5

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