Zinc as a Therapeutic Agent in Bone Regeneration
Zinc is an essential mineral that is required for normal skeletal growth and bone homeostasis. Furthermore, zinc appears to be able to promote bone regeneration. However, the cellular and molecular pathways through which zinc promotes bone growth, homeostasis, and regeneration are poorly understood....
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doaj-8699244e31cb42b7b901c4cbbbe8d6d22020-11-25T02:10:14ZengMDPI AGMaterials1996-19442020-05-01132211221110.3390/ma13102211Zinc as a Therapeutic Agent in Bone RegenerationJ. Patrick O’Connor0Deboleena Kanjilal1Marc Teitelbaum2Sheldon S. Lin3Jessica A. Cottrell4Department of Orthopaedics, Rutgers-New Jersey Medical School, Newark, NJ 07103, USASchool of Graduate Studies, Rutgers, The State University of New Jersey, 185 South Orange Avenue, Newark, NJ 07103, USASchool of Graduate Studies, Rutgers, The State University of New Jersey, 185 South Orange Avenue, Newark, NJ 07103, USADepartment of Orthopaedics, Rutgers-New Jersey Medical School, Newark, NJ 07103, USADepartment of Biological Sciences, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USAZinc is an essential mineral that is required for normal skeletal growth and bone homeostasis. Furthermore, zinc appears to be able to promote bone regeneration. However, the cellular and molecular pathways through which zinc promotes bone growth, homeostasis, and regeneration are poorly understood. Zinc can positively affect chondrocyte and osteoblast functions, while inhibiting osteoclast activity, consistent with a beneficial role for zinc in bone homeostasis and regeneration. Based on the effects of zinc on skeletal cell populations and the role of zinc in skeletal growth, therapeutic approaches using zinc to improve bone regeneration are being developed. This review focuses on the role of zinc in bone growth, homeostasis, and regeneration while providing an overview of the existing studies that use zinc as a bone regeneration therapeutic.https://www.mdpi.com/1996-1944/13/10/2211zincbone regenerationbone healingosteogenesistherapeuticsbone biology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
J. Patrick O’Connor Deboleena Kanjilal Marc Teitelbaum Sheldon S. Lin Jessica A. Cottrell |
spellingShingle |
J. Patrick O’Connor Deboleena Kanjilal Marc Teitelbaum Sheldon S. Lin Jessica A. Cottrell Zinc as a Therapeutic Agent in Bone Regeneration Materials zinc bone regeneration bone healing osteogenesis therapeutics bone biology |
author_facet |
J. Patrick O’Connor Deboleena Kanjilal Marc Teitelbaum Sheldon S. Lin Jessica A. Cottrell |
author_sort |
J. Patrick O’Connor |
title |
Zinc as a Therapeutic Agent in Bone Regeneration |
title_short |
Zinc as a Therapeutic Agent in Bone Regeneration |
title_full |
Zinc as a Therapeutic Agent in Bone Regeneration |
title_fullStr |
Zinc as a Therapeutic Agent in Bone Regeneration |
title_full_unstemmed |
Zinc as a Therapeutic Agent in Bone Regeneration |
title_sort |
zinc as a therapeutic agent in bone regeneration |
publisher |
MDPI AG |
series |
Materials |
issn |
1996-1944 |
publishDate |
2020-05-01 |
description |
Zinc is an essential mineral that is required for normal skeletal growth and bone homeostasis. Furthermore, zinc appears to be able to promote bone regeneration. However, the cellular and molecular pathways through which zinc promotes bone growth, homeostasis, and regeneration are poorly understood. Zinc can positively affect chondrocyte and osteoblast functions, while inhibiting osteoclast activity, consistent with a beneficial role for zinc in bone homeostasis and regeneration. Based on the effects of zinc on skeletal cell populations and the role of zinc in skeletal growth, therapeutic approaches using zinc to improve bone regeneration are being developed. This review focuses on the role of zinc in bone growth, homeostasis, and regeneration while providing an overview of the existing studies that use zinc as a bone regeneration therapeutic. |
topic |
zinc bone regeneration bone healing osteogenesis therapeutics bone biology |
url |
https://www.mdpi.com/1996-1944/13/10/2211 |
work_keys_str_mv |
AT jpatrickoconnor zincasatherapeuticagentinboneregeneration AT deboleenakanjilal zincasatherapeuticagentinboneregeneration AT marcteitelbaum zincasatherapeuticagentinboneregeneration AT sheldonslin zincasatherapeuticagentinboneregeneration AT jessicaacottrell zincasatherapeuticagentinboneregeneration |
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1724920002357755904 |