FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity
Neutrophils are versatile immune cells that may also serve as antigen-presenting cells (APC). Here the authors show that engaging FcγRs on neutrophils with immune complexes or an anti-FcγR-antigen conjugate induces neutrophil APC with comparable functions as classical dendritic cells, and with thera...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24591-x |
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doaj-86a5a1c6c18f436081a1927c18c8de2d2021-08-15T11:40:21ZengNature Publishing GroupNature Communications2041-17232021-08-0112112310.1038/s41467-021-24591-xFcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunityVijayashree Mysore0Xavier Cullere1Joseph Mears2Florencia Rosetti3Koshu Okubo4Pei X. Liew5Fan Zhang6Iris Madera-Salcedo7Frank Rosenbauer8Richard M. Stone9Jon C. Aster10Ulrich H. von Andrian11Andrew H. Lichtman12Soumya Raychaudhuri13Tanya N. Mayadas14Department of Pathology, Brigham and Women’s Hospital and Harvard Medical SchoolDepartment of Pathology, Brigham and Women’s Hospital and Harvard Medical SchoolCenter for Data Sciences, Brigham and Women’s HospitalDepartamento de Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránDepartment of Pathology, Brigham and Women’s Hospital and Harvard Medical SchoolDepartment of Pathology, Brigham and Women’s Hospital and Harvard Medical SchoolCenter for Data Sciences, Brigham and Women’s HospitalDepartamento de Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránInstitute of Molecular Tumor Biology, University of MuensterMedical Oncology, Dana-Farber Cancer Institute and Harvard Medical SchoolDepartment of Pathology, Brigham and Women’s Hospital and Harvard Medical SchoolDepartment of Microbiology and Immunobiology, Harvard Medical SchoolDepartment of Pathology, Brigham and Women’s Hospital and Harvard Medical SchoolCenter for Data Sciences, Brigham and Women’s HospitalDepartment of Pathology, Brigham and Women’s Hospital and Harvard Medical SchoolNeutrophils are versatile immune cells that may also serve as antigen-presenting cells (APC). Here the authors show that engaging FcγRs on neutrophils with immune complexes or an anti-FcγR-antigen conjugate induces neutrophil APC with comparable functions as classical dendritic cells, and with therapeutic potentials for cancer and infectious diseases.https://doi.org/10.1038/s41467-021-24591-x |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Vijayashree Mysore Xavier Cullere Joseph Mears Florencia Rosetti Koshu Okubo Pei X. Liew Fan Zhang Iris Madera-Salcedo Frank Rosenbauer Richard M. Stone Jon C. Aster Ulrich H. von Andrian Andrew H. Lichtman Soumya Raychaudhuri Tanya N. Mayadas |
| spellingShingle |
Vijayashree Mysore Xavier Cullere Joseph Mears Florencia Rosetti Koshu Okubo Pei X. Liew Fan Zhang Iris Madera-Salcedo Frank Rosenbauer Richard M. Stone Jon C. Aster Ulrich H. von Andrian Andrew H. Lichtman Soumya Raychaudhuri Tanya N. Mayadas FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity Nature Communications |
| author_facet |
Vijayashree Mysore Xavier Cullere Joseph Mears Florencia Rosetti Koshu Okubo Pei X. Liew Fan Zhang Iris Madera-Salcedo Frank Rosenbauer Richard M. Stone Jon C. Aster Ulrich H. von Andrian Andrew H. Lichtman Soumya Raychaudhuri Tanya N. Mayadas |
| author_sort |
Vijayashree Mysore |
| title |
FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity |
| title_short |
FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity |
| title_full |
FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity |
| title_fullStr |
FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity |
| title_full_unstemmed |
FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity |
| title_sort |
fcγr engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-08-01 |
| description |
Neutrophils are versatile immune cells that may also serve as antigen-presenting cells (APC). Here the authors show that engaging FcγRs on neutrophils with immune complexes or an anti-FcγR-antigen conjugate induces neutrophil APC with comparable functions as classical dendritic cells, and with therapeutic potentials for cancer and infectious diseases. |
| url |
https://doi.org/10.1038/s41467-021-24591-x |
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