Epidemiological and clinical characteristics and risk factors for death of patients with avian influenza A H7N9 virus infection from Jiangsu Province, Eastern China.
BACKGROUND: A novel avian influenza A (H7N9) virus has caused great morbidity as well as mortality since its emergence in Eastern China in February 2013. However, the possible risk factors for death are not yet fully known. METHODS AND FINDINGS: Patients with H7N9 virus infection between March 1 and...
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doaj-86ad36e9925044aead8edf4120bf46bf2020-11-25T02:09:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0193e8958110.1371/journal.pone.0089581Epidemiological and clinical characteristics and risk factors for death of patients with avian influenza A H7N9 virus infection from Jiangsu Province, Eastern China.Hong JiQin GuLi-Ling ChenKe XuXia LingChang-Jun BaoFen-Yang TangXian QiYing-Qiu WuJing AiGu-Yu ShenDan-Jiang DongHui-Yan YuMao HuangQuan CaoYing XuWei ZhaoYang-Ting XuYu XiaShan-Hui ChenGen-Lin YangCai-Ling GuGuo-Xiang XieYe-Fei ZhuFeng-Cai ZhuMing-Hao ZhouBACKGROUND: A novel avian influenza A (H7N9) virus has caused great morbidity as well as mortality since its emergence in Eastern China in February 2013. However, the possible risk factors for death are not yet fully known. METHODS AND FINDINGS: Patients with H7N9 virus infection between March 1 and August 14, 2013 in Jiangsu province were enrolled. Data were collected with a standard form. Mean or percentage was used to describe the features, and Fisher's exact test or t-test test was used to compare the differences between fatal and nonfatal cases with H7N9 virus infection. A total of 28 patients with H7N9 virus infection were identified among whom, nine (32.1%) died. The median age of fatal cases was significant higher than nonfatal cases (P<0.05). Patients with older age were more strongly associated with increased odds of death (OR = 30.0; 95% CI, 2.85-315.62). Co-morbidity with chronic lung disease and hypertension were risk factors for mortality (OR = 14.40; 95% CI, 1.30-159.52, OR = 6.67; 95% CI, 1.09-40.43, respectively). Moreover, the presence of either bilateral lung inflammation or pulmonary consolidation on chest imaging on admission was related with fatal outcome (OR = 7.00; 95%CI, 1.10-44.61). Finally, dynamic monitoring showed that lymphopenia was more significant in fatal group than in nonfatal group from day 11 to week five (P<0.05). The decrease in oxygenation indexes were observed in most cases and more significantly in fatal cases after week three (P<0.05), and the value of nearly all fatal cases were below 200 mmHg during our evaluation period. CONCLUSIONS: Among cases with H7N9 virus infection, increased age accompanied by co-morbidities was the risk of death. The severity of lung infection at admission, the persistence of lymphocytopenia, and the extended duration of lower oxygenation index all contributed to worsened outcomes of patients with H7N9 virus infection.http://europepmc.org/articles/PMC3942409?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hong Ji Qin Gu Li-Ling Chen Ke Xu Xia Ling Chang-Jun Bao Fen-Yang Tang Xian Qi Ying-Qiu Wu Jing Ai Gu-Yu Shen Dan-Jiang Dong Hui-Yan Yu Mao Huang Quan Cao Ying Xu Wei Zhao Yang-Ting Xu Yu Xia Shan-Hui Chen Gen-Lin Yang Cai-Ling Gu Guo-Xiang Xie Ye-Fei Zhu Feng-Cai Zhu Ming-Hao Zhou |
spellingShingle |
Hong Ji Qin Gu Li-Ling Chen Ke Xu Xia Ling Chang-Jun Bao Fen-Yang Tang Xian Qi Ying-Qiu Wu Jing Ai Gu-Yu Shen Dan-Jiang Dong Hui-Yan Yu Mao Huang Quan Cao Ying Xu Wei Zhao Yang-Ting Xu Yu Xia Shan-Hui Chen Gen-Lin Yang Cai-Ling Gu Guo-Xiang Xie Ye-Fei Zhu Feng-Cai Zhu Ming-Hao Zhou Epidemiological and clinical characteristics and risk factors for death of patients with avian influenza A H7N9 virus infection from Jiangsu Province, Eastern China. PLoS ONE |
author_facet |
Hong Ji Qin Gu Li-Ling Chen Ke Xu Xia Ling Chang-Jun Bao Fen-Yang Tang Xian Qi Ying-Qiu Wu Jing Ai Gu-Yu Shen Dan-Jiang Dong Hui-Yan Yu Mao Huang Quan Cao Ying Xu Wei Zhao Yang-Ting Xu Yu Xia Shan-Hui Chen Gen-Lin Yang Cai-Ling Gu Guo-Xiang Xie Ye-Fei Zhu Feng-Cai Zhu Ming-Hao Zhou |
author_sort |
Hong Ji |
title |
Epidemiological and clinical characteristics and risk factors for death of patients with avian influenza A H7N9 virus infection from Jiangsu Province, Eastern China. |
title_short |
Epidemiological and clinical characteristics and risk factors for death of patients with avian influenza A H7N9 virus infection from Jiangsu Province, Eastern China. |
title_full |
Epidemiological and clinical characteristics and risk factors for death of patients with avian influenza A H7N9 virus infection from Jiangsu Province, Eastern China. |
title_fullStr |
Epidemiological and clinical characteristics and risk factors for death of patients with avian influenza A H7N9 virus infection from Jiangsu Province, Eastern China. |
title_full_unstemmed |
Epidemiological and clinical characteristics and risk factors for death of patients with avian influenza A H7N9 virus infection from Jiangsu Province, Eastern China. |
title_sort |
epidemiological and clinical characteristics and risk factors for death of patients with avian influenza a h7n9 virus infection from jiangsu province, eastern china. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
BACKGROUND: A novel avian influenza A (H7N9) virus has caused great morbidity as well as mortality since its emergence in Eastern China in February 2013. However, the possible risk factors for death are not yet fully known. METHODS AND FINDINGS: Patients with H7N9 virus infection between March 1 and August 14, 2013 in Jiangsu province were enrolled. Data were collected with a standard form. Mean or percentage was used to describe the features, and Fisher's exact test or t-test test was used to compare the differences between fatal and nonfatal cases with H7N9 virus infection. A total of 28 patients with H7N9 virus infection were identified among whom, nine (32.1%) died. The median age of fatal cases was significant higher than nonfatal cases (P<0.05). Patients with older age were more strongly associated with increased odds of death (OR = 30.0; 95% CI, 2.85-315.62). Co-morbidity with chronic lung disease and hypertension were risk factors for mortality (OR = 14.40; 95% CI, 1.30-159.52, OR = 6.67; 95% CI, 1.09-40.43, respectively). Moreover, the presence of either bilateral lung inflammation or pulmonary consolidation on chest imaging on admission was related with fatal outcome (OR = 7.00; 95%CI, 1.10-44.61). Finally, dynamic monitoring showed that lymphopenia was more significant in fatal group than in nonfatal group from day 11 to week five (P<0.05). The decrease in oxygenation indexes were observed in most cases and more significantly in fatal cases after week three (P<0.05), and the value of nearly all fatal cases were below 200 mmHg during our evaluation period. CONCLUSIONS: Among cases with H7N9 virus infection, increased age accompanied by co-morbidities was the risk of death. The severity of lung infection at admission, the persistence of lymphocytopenia, and the extended duration of lower oxygenation index all contributed to worsened outcomes of patients with H7N9 virus infection. |
url |
http://europepmc.org/articles/PMC3942409?pdf=render |
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