Complement inhibition promotes endogenous neurogenesis and sustained anti-inflammatory neuroprotection following reperfused stroke.
The restoration of blood-flow following cerebral ischemia incites a series of deleterious cascades that exacerbate neuronal injury. Pharmacologic inhibition of the C3a-receptor ameliorates cerebral injury by attenuating post-ischemic inflammation. Recent reports also implicate C3a in the modulation...
Main Authors: | Andrew F Ducruet, Brad E Zacharia, Sergey A Sosunov, Paul R Gigante, Mason L Yeh, Justin W Gorski, Marc L Otten, Richard Y Hwang, Peter A DeRosa, Zachary L Hickman, Paulina Sergot, E Sander Connolly |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3383680?pdf=render |
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