Role of SIZN1 in Esophageal Squamous Cell Carcinoma
Background: Bone morphogenetic proteins are a family of cytokines and growth factors that are involved in tumorigenesis. ZCCHC12 (SIZN1), as a transcriptional coactivator of bone morphogenetic protein signaling, is identified as a positive regulator of central nervous system development during embry...
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Shiraz University of Medical Sciences
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doaj-86b141cb7e234fa2991a747ecf9b92e02020-11-25T00:46:34ZengShiraz University of Medical SciencesMiddle East Journal of Cancer 2008-67092008-66872019-01-01101374210.30476/mejc.2019.4468444684Role of SIZN1 in Esophageal Squamous Cell CarcinomaMohammad Mahdi Forghanifard0Mohammad Reza Abbaszadegan1Meysam Moghbeli2Department of Biology, Damghan Branch, Islamic Azad University, Damghan, IranMedical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranBackground: Bone morphogenetic proteins are a family of cytokines and growth factors that are involved in tumorigenesis. ZCCHC12 (SIZN1), as a transcriptional coactivator of bone morphogenetic protein signaling, is identified as a positive regulator of central nervous system development during embryogenesis. It positively regulates the CREB and AP1 transcription factors that cooperate with the bone morphogenetic protein signaling pathway. In the present study, SIZN1 mRNA expression was assessed in esophageal squamous cell carcinoma patients.Methods: The levels of SIZN1 mRNA expression in tumor tissues from 50 patients with esophageal squamous cell carcinoma were compared with their corresponding normal margins by using real-time polymerase chain reaction.Results: We observed that 10 out of 50 (20%) cases overexpressed SIZN1, whereas 40 out of 50 (80%) cases showed either normal or under expression of SIZN1. There was a significant correlation between the levels of SIZN1 mRNA expression and tumor depth of invasion (P=0.040). Furthermore, a significant correlation between lymph node metastasis and SIZN1 mRNA expression was observed in esophageal squamous cell carcinoma patients (P=0.036).Conclusion: This study is the first report that has assessed SIZN1 expression in esophageal squamous cell carcinoma patients. SIZN1 can be a potential therapeutic target for primary esophageal squamous cell carcinoma because of its role in the early stages of tumor progression and metastasis.http://mejc.sums.ac.ir/article_44684_e5ce2c11da4e85c9f34c2e113ba93d90.pdf |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohammad Mahdi Forghanifard Mohammad Reza Abbaszadegan Meysam Moghbeli |
spellingShingle |
Mohammad Mahdi Forghanifard Mohammad Reza Abbaszadegan Meysam Moghbeli Role of SIZN1 in Esophageal Squamous Cell Carcinoma Middle East Journal of Cancer |
author_facet |
Mohammad Mahdi Forghanifard Mohammad Reza Abbaszadegan Meysam Moghbeli |
author_sort |
Mohammad Mahdi Forghanifard |
title |
Role of SIZN1 in Esophageal Squamous Cell Carcinoma |
title_short |
Role of SIZN1 in Esophageal Squamous Cell Carcinoma |
title_full |
Role of SIZN1 in Esophageal Squamous Cell Carcinoma |
title_fullStr |
Role of SIZN1 in Esophageal Squamous Cell Carcinoma |
title_full_unstemmed |
Role of SIZN1 in Esophageal Squamous Cell Carcinoma |
title_sort |
role of sizn1 in esophageal squamous cell carcinoma |
publisher |
Shiraz University of Medical Sciences |
series |
Middle East Journal of Cancer |
issn |
2008-6709 2008-6687 |
publishDate |
2019-01-01 |
description |
Background: Bone morphogenetic proteins are a family of cytokines and growth factors that are involved in tumorigenesis. ZCCHC12 (SIZN1), as a transcriptional coactivator of bone morphogenetic protein signaling, is identified as a positive regulator of central nervous system development during embryogenesis. It positively regulates the CREB and AP1 transcription factors that cooperate with the bone morphogenetic protein signaling pathway. In the present study, SIZN1 mRNA expression was assessed in esophageal squamous cell carcinoma patients.Methods: The levels of SIZN1 mRNA expression in tumor tissues from 50 patients with esophageal squamous cell carcinoma were compared with their corresponding normal margins by using real-time polymerase chain reaction.Results: We observed that 10 out of 50 (20%) cases overexpressed SIZN1, whereas 40 out of 50 (80%) cases showed either normal or under expression of SIZN1. There was a significant correlation between the levels of SIZN1 mRNA expression and tumor depth of invasion (P=0.040). Furthermore, a significant correlation between lymph node metastasis and SIZN1 mRNA expression was observed in esophageal squamous cell carcinoma patients (P=0.036).Conclusion: This study is the first report that has assessed SIZN1 expression in esophageal squamous cell carcinoma patients. SIZN1 can be a potential therapeutic target for primary esophageal squamous cell carcinoma because of its role in the early stages of tumor progression and metastasis. |
url |
http://mejc.sums.ac.ir/article_44684_e5ce2c11da4e85c9f34c2e113ba93d90.pdf |
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