The emerging role of SPOP protein in tumorigenesis and cancer therapy
Abstract The nuclear speckle-type pox virus and zinc finger (POZ) protein (SPOP), a representative substrate-recognition subunit of the cullin-RING E3 ligase, has been characterized to play a dual role in tumorigenesis and cancer progression. Numerous studies have determined that SPOP suppresses tum...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2020-01-01
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Series: | Molecular Cancer |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12943-019-1124-x |