LINC00473 as an Immediate Early Gene under the Control of the EGR1 Transcription Facto
Immediate early genes play an essential role in cellular responses to different stimuli. Many of them are transcription factors that regulate the secondary response gene expression. Non-coding RNAs may also be involved in this regulatory cascade. In fact, they are emerging as key actors of gene expr...
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doaj-86b606fae08243fd9bd0dc0976e0f3e62020-11-25T04:07:03ZengMDPI AGNon-Coding RNA2311-553X2020-11-016464610.3390/ncrna6040046LINC00473 as an Immediate Early Gene under the Control of the EGR1 Transcription FactoVincenza Aliperti0Emilia Vitale1Francesco Aniello2Aldo Donizetti3Department of Biology, University of Naples Federico II, 80126 Naples, ItalyNeurOmics Laboratory, Institute of Protein Biochemistry (IBP), CNR, 80131 Naples, ItalyDepartment of Biology, University of Naples Federico II, 80126 Naples, ItalyDepartment of Biology, University of Naples Federico II, 80126 Naples, ItalyImmediate early genes play an essential role in cellular responses to different stimuli. Many of them are transcription factors that regulate the secondary response gene expression. Non-coding RNAs may also be involved in this regulatory cascade. In fact, they are emerging as key actors of gene expression regulation, and evidence suggests that their dysregulation may underly pathological states. We previously took a snapshot of both coding and long non-coding RNAs differentially expressed in neuronal cells after brain-derived neurotrophic factor stimulation. Among these, the transcription factor EGR1 (a well-known immediate early gene) and LINC00473 (a primate-specific long non-coding RNA) that has emerged as an interesting RNA candidate involved in neuronal function and in cancer. In this work, we demonstrated that LINC00473 gene expression kinetics resembled that of immediate early genes in SH-SY5Y and HEK293T cells under different cell stimulation conditions. Moreover, we showed that the expression of LINC00473 is under the control of the transcription factor EGR1, providing evidence for an interesting functional relationship in neuron function.https://www.mdpi.com/2311-553X/6/4/46immediate-early geneslong non-coding RNAsLINC00473C6orf176EGR1BDNF |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vincenza Aliperti Emilia Vitale Francesco Aniello Aldo Donizetti |
spellingShingle |
Vincenza Aliperti Emilia Vitale Francesco Aniello Aldo Donizetti LINC00473 as an Immediate Early Gene under the Control of the EGR1 Transcription Facto Non-Coding RNA immediate-early genes long non-coding RNAs LINC00473 C6orf176 EGR1 BDNF |
author_facet |
Vincenza Aliperti Emilia Vitale Francesco Aniello Aldo Donizetti |
author_sort |
Vincenza Aliperti |
title |
LINC00473 as an Immediate Early Gene under the Control of the EGR1 Transcription Facto |
title_short |
LINC00473 as an Immediate Early Gene under the Control of the EGR1 Transcription Facto |
title_full |
LINC00473 as an Immediate Early Gene under the Control of the EGR1 Transcription Facto |
title_fullStr |
LINC00473 as an Immediate Early Gene under the Control of the EGR1 Transcription Facto |
title_full_unstemmed |
LINC00473 as an Immediate Early Gene under the Control of the EGR1 Transcription Facto |
title_sort |
linc00473 as an immediate early gene under the control of the egr1 transcription facto |
publisher |
MDPI AG |
series |
Non-Coding RNA |
issn |
2311-553X |
publishDate |
2020-11-01 |
description |
Immediate early genes play an essential role in cellular responses to different stimuli. Many of them are transcription factors that regulate the secondary response gene expression. Non-coding RNAs may also be involved in this regulatory cascade. In fact, they are emerging as key actors of gene expression regulation, and evidence suggests that their dysregulation may underly pathological states. We previously took a snapshot of both coding and long non-coding RNAs differentially expressed in neuronal cells after brain-derived neurotrophic factor stimulation. Among these, the transcription factor EGR1 (a well-known immediate early gene) and LINC00473 (a primate-specific long non-coding RNA) that has emerged as an interesting RNA candidate involved in neuronal function and in cancer. In this work, we demonstrated that LINC00473 gene expression kinetics resembled that of immediate early genes in SH-SY5Y and HEK293T cells under different cell stimulation conditions. Moreover, we showed that the expression of LINC00473 is under the control of the transcription factor EGR1, providing evidence for an interesting functional relationship in neuron function. |
topic |
immediate-early genes long non-coding RNAs LINC00473 C6orf176 EGR1 BDNF |
url |
https://www.mdpi.com/2311-553X/6/4/46 |
work_keys_str_mv |
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