Human intestinal models to study interactions between intestine and microbes
Implementations of suitable in vitro cell culture systems of the human intestine have been essential tools in the study of the interaction among organs, commensal microbiota, pathogens and parasites. Due to the great complexity exhibited by the intestinal tissue, researchers have been developing in...
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The Royal Society
2020-10-01
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Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200199 |
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doaj-86b94f89f3ea4700928bb7b963b7c9532020-11-25T04:01:58ZengThe Royal SocietyOpen Biology2046-24412020-10-01101010.1098/rsob.200199200199Human intestinal models to study interactions between intestine and microbesArturo Aguilar-RojasJean-Christophe Olivo-MarinNancy GuillenImplementations of suitable in vitro cell culture systems of the human intestine have been essential tools in the study of the interaction among organs, commensal microbiota, pathogens and parasites. Due to the great complexity exhibited by the intestinal tissue, researchers have been developing in vitro/ex vivo systems to diminish the gap between conventional cell culture models and the human intestine. These models are able to reproduce different structures and functional aspects of the tissue. In the present review, information is recapitulated on the most used models, such as cell culture, intestinal organoids, scaffold-based three-dimensional models, and organ-on-a-chip and their use in studying the interaction between human intestine and microbes, and their advantages and limitations are also discussed.https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200199intestinal cell cultureorganoidsthree-dimensional (3d) scaffoldsorgan-on-a-chipmicrobiotaparasites |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Arturo Aguilar-Rojas Jean-Christophe Olivo-Marin Nancy Guillen |
spellingShingle |
Arturo Aguilar-Rojas Jean-Christophe Olivo-Marin Nancy Guillen Human intestinal models to study interactions between intestine and microbes Open Biology intestinal cell culture organoids three-dimensional (3d) scaffolds organ-on-a-chip microbiota parasites |
author_facet |
Arturo Aguilar-Rojas Jean-Christophe Olivo-Marin Nancy Guillen |
author_sort |
Arturo Aguilar-Rojas |
title |
Human intestinal models to study interactions between intestine and microbes |
title_short |
Human intestinal models to study interactions between intestine and microbes |
title_full |
Human intestinal models to study interactions between intestine and microbes |
title_fullStr |
Human intestinal models to study interactions between intestine and microbes |
title_full_unstemmed |
Human intestinal models to study interactions between intestine and microbes |
title_sort |
human intestinal models to study interactions between intestine and microbes |
publisher |
The Royal Society |
series |
Open Biology |
issn |
2046-2441 |
publishDate |
2020-10-01 |
description |
Implementations of suitable in vitro cell culture systems of the human intestine have been essential tools in the study of the interaction among organs, commensal microbiota, pathogens and parasites. Due to the great complexity exhibited by the intestinal tissue, researchers have been developing in vitro/ex vivo systems to diminish the gap between conventional cell culture models and the human intestine. These models are able to reproduce different structures and functional aspects of the tissue. In the present review, information is recapitulated on the most used models, such as cell culture, intestinal organoids, scaffold-based three-dimensional models, and organ-on-a-chip and their use in studying the interaction between human intestine and microbes, and their advantages and limitations are also discussed. |
topic |
intestinal cell culture organoids three-dimensional (3d) scaffolds organ-on-a-chip microbiota parasites |
url |
https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200199 |
work_keys_str_mv |
AT arturoaguilarrojas humanintestinalmodelstostudyinteractionsbetweenintestineandmicrobes AT jeanchristopheolivomarin humanintestinalmodelstostudyinteractionsbetweenintestineandmicrobes AT nancyguillen humanintestinalmodelstostudyinteractionsbetweenintestineandmicrobes |
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1724444865646821376 |