The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells
Summary: GPR4 is a pH-sensing G protein-coupled receptor highly expressed in vascular endothelial cells and can be activated by protons in the inflamed tissue microenvironment. Herein, we report that acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular e...
Main Authors: | Elizabeth A. Krewson, Edward J. Sanderlin, Mona A. Marie, Shayan Nik Akhtar, Juraj Velcicky, Pius Loetscher, Li V. Yang |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2020-02-01
|
Series: | iScience |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004220300316 |
Similar Items
-
Endothelial domes encapsulate adherent neutrophils and minimize increases in vascular permeability in paracellular and transcellular emigration.
by: Mia Phillipson, et al.
Published: (2008-01-01) -
Effect of Lactobacilli on Paracellular Permeability in the Gut
by: Marie-Louise Johansson Hagslatt, et al.
Published: (2011-01-01) -
Acidosis Activates Endoplasmic Reticulum Stress Pathways through GPR4 in Human Vascular Endothelial Cells
by: Lixue Dong, et al.
Published: (2017-01-01) -
Modulation of paracellular permeability and intercellular junctions in cultured epithelia
by: Collares Buzato, Carla Beatriz
Published: (1995) -
An on-chip model of protein paracellular and transcellular permeability in the microcirculation
by: Offeddu, Giovanni, et al.
Published: (2020)