Critical Role of Gap Junction Coupled K(ATP)Channel Activity for Regulated Insulin Secretion.
Pancreatic beta-cells secrete insulin in response to closure of ATP-sensitive K(+) (K(ATP)) channels, which causes membrane depolarization and a concomitant rise in intracellular Ca(2+) (Ca(i)). In intact islets, beta-cells are coupled by gap junctions, which are proposed to synchronize electrical a...
| Format: | Article |
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| Language: | English |
| Published: |
Public Library of Science (PLoS)
2006-01-01
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| Series: | PLoS Biology |
| Online Access: | http://dx.doi.org/10.1371/journal.pbio.0040026 |