Synergy Between Beta-Lactams and Lipo-, Glyco-, and Lipoglycopeptides, Is Independent of the Seesaw Effect in Methicillin-Resistant Staphylococcus aureus

Synergy Between Beta-Lactams and Lipo-, Glyco-, and Lipoglycopeptides, Is Independent of the Seesaw Effect in Methicillin-Resistant Staphylococcus aureus

Methicillin-resistant S. aureus (MRSA) are resistant to beta-lactams, but synergistic activity between beta-lactams and glycopeptides/lipopeptides is common. Many have attributed this synergy to the beta-lactam-glycopeptide seesaw effect; however, this association has not been rigorously tested. The...

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Bibliographic Details
Main Authors: Rutan Zhang, Ismael A. Barreras Beltran, Nathaniel K. Ashford, Kelsi Penewit, Adam Waalkes, Elizabeth A. Holmes, Kelly M. Hines, Stephen J. Salipante, Libin Xu, Brian J. Werth
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
seesaw effect
beta-lactam antibacterials
lipidomic analysis
vancomycin
daptomycin
dalbavancin
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.688357/full

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