Bone and Muscle Crosstalk in Aging
Osteoporosis and sarcopenia are two age-related diseases that affect the quality of life in the elderly. Initially, they were thought to be two independent diseases; however, recently, increasing basic and clinical data suggest that skeletal muscle and bone are both spatially and metabolically conne...
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doaj-86e3137d440046aab66e407c0d9d805a2020-12-10T04:47:49ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-12-01810.3389/fcell.2020.585644585644Bone and Muscle Crosstalk in AgingChen He0Wenzhen He1Jing Hou2Kaixuan Chen3Mei Huang4Mi Yang5Xianghang Luo6Xianghang Luo7Xianghang Luo8Changjun Li9Changjun Li10Changjun Li11Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, ChinaKey Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, ChinaDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, ChinaKey Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, ChinaOsteoporosis and sarcopenia are two age-related diseases that affect the quality of life in the elderly. Initially, they were thought to be two independent diseases; however, recently, increasing basic and clinical data suggest that skeletal muscle and bone are both spatially and metabolically connected. The term “osteosarcopenia” is used to define a condition of synergy of low bone mineral density with muscle atrophy and hypofunction. Bone and muscle cells secrete several factors, such as cytokines, myokines, and osteokines, into the circulation to influence the biological and pathological activities in local and distant organs and cells. Recent studies reveal that extracellular vesicles containing microRNAs derived from senescent skeletal muscle and bone cells can also be transported and aid in regulating bone-muscle crosstalk. In this review, we summarize the age-related changes in the secretome and extracellular vesicle-microRNAs secreted by the muscle and bone, and discuss their interactions between muscle and bone cells during aging.https://www.frontiersin.org/articles/10.3389/fcell.2020.585644/fullbonemusclecrosstalkagingosteosarcopenia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chen He Wenzhen He Jing Hou Kaixuan Chen Mei Huang Mi Yang Xianghang Luo Xianghang Luo Xianghang Luo Changjun Li Changjun Li Changjun Li |
spellingShingle |
Chen He Wenzhen He Jing Hou Kaixuan Chen Mei Huang Mi Yang Xianghang Luo Xianghang Luo Xianghang Luo Changjun Li Changjun Li Changjun Li Bone and Muscle Crosstalk in Aging Frontiers in Cell and Developmental Biology bone muscle crosstalk aging osteosarcopenia |
author_facet |
Chen He Wenzhen He Jing Hou Kaixuan Chen Mei Huang Mi Yang Xianghang Luo Xianghang Luo Xianghang Luo Changjun Li Changjun Li Changjun Li |
author_sort |
Chen He |
title |
Bone and Muscle Crosstalk in Aging |
title_short |
Bone and Muscle Crosstalk in Aging |
title_full |
Bone and Muscle Crosstalk in Aging |
title_fullStr |
Bone and Muscle Crosstalk in Aging |
title_full_unstemmed |
Bone and Muscle Crosstalk in Aging |
title_sort |
bone and muscle crosstalk in aging |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2020-12-01 |
description |
Osteoporosis and sarcopenia are two age-related diseases that affect the quality of life in the elderly. Initially, they were thought to be two independent diseases; however, recently, increasing basic and clinical data suggest that skeletal muscle and bone are both spatially and metabolically connected. The term “osteosarcopenia” is used to define a condition of synergy of low bone mineral density with muscle atrophy and hypofunction. Bone and muscle cells secrete several factors, such as cytokines, myokines, and osteokines, into the circulation to influence the biological and pathological activities in local and distant organs and cells. Recent studies reveal that extracellular vesicles containing microRNAs derived from senescent skeletal muscle and bone cells can also be transported and aid in regulating bone-muscle crosstalk. In this review, we summarize the age-related changes in the secretome and extracellular vesicle-microRNAs secreted by the muscle and bone, and discuss their interactions between muscle and bone cells during aging. |
topic |
bone muscle crosstalk aging osteosarcopenia |
url |
https://www.frontiersin.org/articles/10.3389/fcell.2020.585644/full |
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