Systems Biology Analysis of the Radiation-Attenuated Schistosome Vaccine Reveals a Role for Growth Factors in Protection and Hemostasis Inhibition in Parasite Survival

Systems Biology Analysis of the Radiation-Attenuated Schistosome Vaccine Reveals a Role for Growth Factors in Protection and Hemostasis Inhibition in Parasite Survival

In spite of several decades of research, an effective vaccine against schistosomiasis remains elusive. The radiation-attenuated (RA) cercarial vaccine is still the best model eliciting high protection levels, although the immune mechanisms have not yet been fully characterized. In order to identify...

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Bibliographic Details
Main Authors: Leonardo Paiva Farias, Juliana Vitoriano-Souza, Lucas Esteves Cardozo, Leonardo Dos Reis Gama, Youvika Singh, Patrícia Aoki Miyasato, Giulliana Tessarin Almeida, Dunia Rodriguez, Mayra Mara Ferrari Barbosa, Rafaela Sachetto Fernandes, Tereza Cristina Barbosa, Almiro Pires da Silva Neto, Eliana Nakano, Paulo Lee Ho, Sergio Verjovski-Almeida, Helder Imoto Nakaya, Robert Alan Wilson, Luciana Cezar de Cerqueira Leite
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
Schistosoma mansoni
radiation-attenuated vaccine
systems biology
immune response
protection mechanism
mouse model
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.624191/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.624191/full

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