Association between thyroid hormones and the components of metabolic syndrome
Abstract Background Thyroid hormones are known to have direct and indirect effects on metabolism. Individuals with metabolic syndrome, a disease that is growing in incidence at a rapid rate, are at higher risk for cardiovascular disease, diabetes, and cancer. The aim of this study was to identify wh...
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doaj-86e8656f46c746d4b82435c789ceafef2020-11-25T03:46:45ZengBMCBMC Endocrine Disorders1472-68232018-05-011811910.1186/s12902-018-0256-0Association between thyroid hormones and the components of metabolic syndromeJieun Jang0Youngsook Kim1Jaeyong Shin2Sang Ah Lee3Young Choi4Eun-Cheol Park5Department of Public Health, Graduate School, Yonsei UniversityDepartment of Anesthesia, Indiana University School of MedicineInstitute of Health Services Research, Yonsei UniversityDepartment of Public Health, Graduate School, Yonsei UniversityDepartment of Public Health, Graduate School, Yonsei UniversityInstitute of Health Services Research, Yonsei UniversityAbstract Background Thyroid hormones are known to have direct and indirect effects on metabolism. Individuals with metabolic syndrome, a disease that is growing in incidence at a rapid rate, are at higher risk for cardiovascular disease, diabetes, and cancer. The aim of this study was to identify whether significant correlations exist between thyroid hormone levels and components of the metabolic syndrome in the general population of Korea. Methods The data were collected from the sixth Korea National Health and Nutrition Examination Surveys from 2013 to 2015. A total of 1423 participants were tested for thyroid function. The analysis of variance and multiple linear regression were performed to analyze the relationship between thyroid hormone level and components of the metabolic syndrome. Results A positive association between free thyroxine and fasting glucose level was observed in patients with high free thyroxine levels (≥1.70 ng/dL, β = 15.992, p = < 0.0001), when compared with patients with normal-middle free thyroxine levels. Moreover, a negative association was observed between free thyroxine and triglyceride levels in patients with normal-high free thyroxine levels (β = − 21.145, p = 0.0054) and those with high free thyroxine levels (β = − 49.713, p = 0.0404). Conclusion Free thyroxine shows a partially positive association with fasting glucose and a partially negative association with triglycerides in the Korean population. In patients with abnormal thyroid function, follow up tests for glucose levels and lipid profiling during treatment for thyroid dysfunction would be beneficial in terms of overlooking metabolic syndrome and to prevent related diseases.http://link.springer.com/article/10.1186/s12902-018-0256-0Thyroid hormoneMetabolic syndromeFree thyroxineFT4 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jieun Jang Youngsook Kim Jaeyong Shin Sang Ah Lee Young Choi Eun-Cheol Park |
spellingShingle |
Jieun Jang Youngsook Kim Jaeyong Shin Sang Ah Lee Young Choi Eun-Cheol Park Association between thyroid hormones and the components of metabolic syndrome BMC Endocrine Disorders Thyroid hormone Metabolic syndrome Free thyroxine FT4 |
author_facet |
Jieun Jang Youngsook Kim Jaeyong Shin Sang Ah Lee Young Choi Eun-Cheol Park |
author_sort |
Jieun Jang |
title |
Association between thyroid hormones and the components of metabolic syndrome |
title_short |
Association between thyroid hormones and the components of metabolic syndrome |
title_full |
Association between thyroid hormones and the components of metabolic syndrome |
title_fullStr |
Association between thyroid hormones and the components of metabolic syndrome |
title_full_unstemmed |
Association between thyroid hormones and the components of metabolic syndrome |
title_sort |
association between thyroid hormones and the components of metabolic syndrome |
publisher |
BMC |
series |
BMC Endocrine Disorders |
issn |
1472-6823 |
publishDate |
2018-05-01 |
description |
Abstract Background Thyroid hormones are known to have direct and indirect effects on metabolism. Individuals with metabolic syndrome, a disease that is growing in incidence at a rapid rate, are at higher risk for cardiovascular disease, diabetes, and cancer. The aim of this study was to identify whether significant correlations exist between thyroid hormone levels and components of the metabolic syndrome in the general population of Korea. Methods The data were collected from the sixth Korea National Health and Nutrition Examination Surveys from 2013 to 2015. A total of 1423 participants were tested for thyroid function. The analysis of variance and multiple linear regression were performed to analyze the relationship between thyroid hormone level and components of the metabolic syndrome. Results A positive association between free thyroxine and fasting glucose level was observed in patients with high free thyroxine levels (≥1.70 ng/dL, β = 15.992, p = < 0.0001), when compared with patients with normal-middle free thyroxine levels. Moreover, a negative association was observed between free thyroxine and triglyceride levels in patients with normal-high free thyroxine levels (β = − 21.145, p = 0.0054) and those with high free thyroxine levels (β = − 49.713, p = 0.0404). Conclusion Free thyroxine shows a partially positive association with fasting glucose and a partially negative association with triglycerides in the Korean population. In patients with abnormal thyroid function, follow up tests for glucose levels and lipid profiling during treatment for thyroid dysfunction would be beneficial in terms of overlooking metabolic syndrome and to prevent related diseases. |
topic |
Thyroid hormone Metabolic syndrome Free thyroxine FT4 |
url |
http://link.springer.com/article/10.1186/s12902-018-0256-0 |
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