Effects of adjuvant ginkgolide injection therapy in perioperative period of hypertensive cerebral hemorrhage on neural functional recovery
Objective: To study the effects of adjuvant ginkgolide injection therapy in perioperative period of hypertensive cerebral hemorrhage on neural functional recovery. Methods: Patients with hypertensive cerebral hemorrhage who underwent evacuation of hematoma in Traditional Chinese Medicine Hospital...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2018-12-01
|
| Series: | Journal of Hainan Medical University |
| Subjects: | |
| Online Access: | http://www.hnykdxxb.com/PDF/201812/16.pdf |
| Summary: | Objective: To study the effects of adjuvant ginkgolide injection therapy in perioperative period
of hypertensive cerebral hemorrhage on neural functional recovery. Methods: Patients with
hypertensive cerebral hemorrhage who underwent evacuation of hematoma in Traditional
Chinese Medicine Hospital of Shunyi District Beijing between June 2015 and October 2017
were selected and divided into ginkgolide group and normal control group according to the
perioperative application of ginkgolide injection or not in the history data. The levels of
nerve injury markers and inflammatory stress mediators in serum as well as the expression of
inflammatory stress signal molecules in peripheral blood were measured before treatment and
7 d after treatment. Results: Compared with same group before treatment, serum GNS and
BDNF levels as well as peripheral blood Wnt1, GSK-3β and β-catenin expression of both
groups of patients were significantly higher whereas serum Tau, NSE, OPN, MIF, HMGB1,
TNF-α and MDA levels as well as peripheral blood eNOS and p38MAPK expression were
significantly lower 7 d after treatment, and serum GNS and BDNF levels as well as peripheral
blood Wnt1, GSK-3β and β-catenin expression of ginkgolide group 7 d after treatment were
higher than those of normal control group whereas serum Tau, NSE, OPN, MIF, HMGB1,
TNF-α and MDA levels as well as peripheral blood eNOS and p38MAPK expression were
lower than those of normal control group. Conclusion: Adjuvant ginkgolide injection therapy
in perioperative period of hypertensive cerebral hemorrhage can reduce the degree of nerve
injury and inhibit the degree of inflammatory |
|---|---|
| ISSN: | 1007-1237 1007-1237 |