Chronic glomerulonephritis and pregnancy
Aim. To clarify factors of risk for unfavourable variants of gestational chronic glomerulonephritis (CGN) and poor pregnancy outcomes in CGN; to determine prognostic implications of changes in some renal and uteroplacental indices. Material and methods. Variants of CGN gestational course and pregnan...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | Russian |
Published: |
"Consilium Medicum" Publishing house
2004-09-01
|
Series: | Терапевтический архив |
Subjects: | |
Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/29880 |
id |
doaj-86ea5d1ab24a4a4897d4ca9a6ff7692b |
---|---|
record_format |
Article |
spelling |
doaj-86ea5d1ab24a4a4897d4ca9a6ff7692b2020-11-25T03:05:23Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422004-09-01799212526908Chronic glomerulonephritis and pregnancyV A RogovE M ShilovN L KozlovskayaN В GordovskayaO V NikiforovaI O MakarovA P MilovanovAim. To clarify factors of risk for unfavourable variants of gestational chronic glomerulonephritis (CGN) and poor pregnancy outcomes in CGN; to determine prognostic implications of changes in some renal and uteroplacental indices. Material and methods. Variants of CGN gestational course and pregnancy outcomes have been analysed for 156 CGN patients. The women were examined before pregnancy, in the course of pregnancy and 3-24 months after the delivery. Measurements were made of 24 h proteinuria, glomerular filtration rate, blood transaminases activity, functional renal reserve (FRR), uricemia, blood level ofalphaphetoprotein. Placentas were studied morphologically, uterine and umbilical artery circulation was assessed by dopplerometry. Results. The following abnormalities were registered: high proteinuria (34.6%), progression of hypertension (29.5%), renal function deterioration (15.4%), fetal and neonatal losses (15.4%), fetal underdevelopment (25%), preterm delivery (17.3%), preeclampsia (7.7%), preterm placental detachment (1.9%). There is morphological, dopplerometric and biochemical evidence for placental insufficiency in CGN pregnant women. Conclusion. Activity of CGN (nephritic or acute nephritic syndromes), hypertension, renal failure, disorders of renal hemodynamics are factors of risk for unfavourable gestational course of CGN and pregnancy complications. Placental insufficiency deteriorates pregnancy outcomes in CGN, but changes in uterine and umbilical circulation as well as blood levels of alpha-fetoprotein are not prognostically significant.https://ter-arkhiv.ru/0040-3660/article/view/29880chronic glomerulonephritispregnancyplacental insufficiencyfunctional renal reserveblood flow in uterine arteriesfetal losspreterm delivery |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
V A Rogov E M Shilov N L Kozlovskaya N В Gordovskaya O V Nikiforova I O Makarov A P Milovanov |
spellingShingle |
V A Rogov E M Shilov N L Kozlovskaya N В Gordovskaya O V Nikiforova I O Makarov A P Milovanov Chronic glomerulonephritis and pregnancy Терапевтический архив chronic glomerulonephritis pregnancy placental insufficiency functional renal reserve blood flow in uterine arteries fetal loss preterm delivery |
author_facet |
V A Rogov E M Shilov N L Kozlovskaya N В Gordovskaya O V Nikiforova I O Makarov A P Milovanov |
author_sort |
V A Rogov |
title |
Chronic glomerulonephritis and pregnancy |
title_short |
Chronic glomerulonephritis and pregnancy |
title_full |
Chronic glomerulonephritis and pregnancy |
title_fullStr |
Chronic glomerulonephritis and pregnancy |
title_full_unstemmed |
Chronic glomerulonephritis and pregnancy |
title_sort |
chronic glomerulonephritis and pregnancy |
publisher |
"Consilium Medicum" Publishing house |
series |
Терапевтический архив |
issn |
0040-3660 2309-5342 |
publishDate |
2004-09-01 |
description |
Aim. To clarify factors of risk for unfavourable variants of gestational chronic glomerulonephritis
(CGN) and poor pregnancy outcomes in CGN; to determine prognostic implications of changes in
some renal and uteroplacental indices.
Material and methods. Variants of CGN gestational course and pregnancy outcomes have been analysed for 156 CGN patients. The women were examined before pregnancy, in the course of pregnancy
and 3-24 months after the delivery. Measurements were made of 24 h proteinuria, glomerular filtration rate, blood transaminases activity, functional renal reserve (FRR), uricemia, blood level ofalphaphetoprotein. Placentas were studied morphologically, uterine and umbilical artery circulation was assessed by dopplerometry.
Results. The following abnormalities were registered: high proteinuria (34.6%), progression of hypertension (29.5%), renal function deterioration (15.4%), fetal and neonatal losses (15.4%), fetal underdevelopment (25%), preterm delivery (17.3%), preeclampsia (7.7%), preterm placental detachment
(1.9%). There is morphological, dopplerometric and biochemical evidence for placental insufficiency
in CGN pregnant women.
Conclusion. Activity of CGN (nephritic or acute nephritic syndromes), hypertension, renal failure, disorders of renal hemodynamics are factors of risk for unfavourable gestational course of CGN and
pregnancy complications. Placental insufficiency deteriorates pregnancy outcomes in CGN, but changes in uterine and umbilical circulation as well as blood levels of alpha-fetoprotein are not prognostically significant. |
topic |
chronic glomerulonephritis pregnancy placental insufficiency functional renal reserve blood flow in uterine arteries fetal loss preterm delivery |
url |
https://ter-arkhiv.ru/0040-3660/article/view/29880 |
work_keys_str_mv |
AT varogov chronicglomerulonephritisandpregnancy AT emshilov chronicglomerulonephritisandpregnancy AT nlkozlovskaya chronicglomerulonephritisandpregnancy AT nvgordovskaya chronicglomerulonephritisandpregnancy AT ovnikiforova chronicglomerulonephritisandpregnancy AT iomakarov chronicglomerulonephritisandpregnancy AT apmilovanov chronicglomerulonephritisandpregnancy |
_version_ |
1724678947690512384 |