Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis
Patients with solid cancers have high rates of clonal haematopoiesis associated with increased risk of secondary leukemias. Here, by using peripheral blood sequencing data from patients with solid non-hematologic cancer, the authors profile the landscape of mosaic chromosomal alterations and gene mu...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20565-7 |
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doaj-86f1527efcbe4a8c928f5380279e4756 |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Teng Gao Ryan Ptashkin Kelly L. Bolton Maria Sirenko Christopher Fong Barbara Spitzer Kamal Menghrajani Juan E. Arango Ossa Yangyu Zhou Elsa Bernard Max Levine Juan S. Medina Martinez Yanming Zhang Sebastià Franch-Expósito Minal Patel Lior Z. Braunstein Daniel Kelly Mariko Yabe Ryma Benayed Nicole M. Caltabellotta John Philip Ederlinda Paraiso Simon Mantha David B. Solit Luis A. Diaz Michael F. Berger Virginia Klimek Ross L. Levine Ahmet Zehir Sean M. Devlin Elli Papaemmanuil |
| spellingShingle |
Teng Gao Ryan Ptashkin Kelly L. Bolton Maria Sirenko Christopher Fong Barbara Spitzer Kamal Menghrajani Juan E. Arango Ossa Yangyu Zhou Elsa Bernard Max Levine Juan S. Medina Martinez Yanming Zhang Sebastià Franch-Expósito Minal Patel Lior Z. Braunstein Daniel Kelly Mariko Yabe Ryma Benayed Nicole M. Caltabellotta John Philip Ederlinda Paraiso Simon Mantha David B. Solit Luis A. Diaz Michael F. Berger Virginia Klimek Ross L. Levine Ahmet Zehir Sean M. Devlin Elli Papaemmanuil Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis Nature Communications |
| author_facet |
Teng Gao Ryan Ptashkin Kelly L. Bolton Maria Sirenko Christopher Fong Barbara Spitzer Kamal Menghrajani Juan E. Arango Ossa Yangyu Zhou Elsa Bernard Max Levine Juan S. Medina Martinez Yanming Zhang Sebastià Franch-Expósito Minal Patel Lior Z. Braunstein Daniel Kelly Mariko Yabe Ryma Benayed Nicole M. Caltabellotta John Philip Ederlinda Paraiso Simon Mantha David B. Solit Luis A. Diaz Michael F. Berger Virginia Klimek Ross L. Levine Ahmet Zehir Sean M. Devlin Elli Papaemmanuil |
| author_sort |
Teng Gao |
| title |
Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis |
| title_short |
Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis |
| title_full |
Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis |
| title_fullStr |
Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis |
| title_full_unstemmed |
Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis |
| title_sort |
interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-01-01 |
| description |
Patients with solid cancers have high rates of clonal haematopoiesis associated with increased risk of secondary leukemias. Here, by using peripheral blood sequencing data from patients with solid non-hematologic cancer, the authors profile the landscape of mosaic chromosomal alterations and gene mutations, defining patients at high risk of leukemia progression. |
| url |
https://doi.org/10.1038/s41467-020-20565-7 |
| work_keys_str_mv |
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1724335270341378048 |
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doaj-86f1527efcbe4a8c928f5380279e47562021-01-17T12:13:39ZengNature Publishing GroupNature Communications2041-17232021-01-0112111110.1038/s41467-020-20565-7Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesisTeng Gao0Ryan Ptashkin1Kelly L. Bolton2Maria Sirenko3Christopher Fong4Barbara Spitzer5Kamal Menghrajani6Juan E. Arango Ossa7Yangyu Zhou8Elsa Bernard9Max Levine10Juan S. Medina Martinez11Yanming Zhang12Sebastià Franch-Expósito13Minal Patel14Lior Z. Braunstein15Daniel Kelly16Mariko Yabe17Ryma Benayed18Nicole M. Caltabellotta19John Philip20Ederlinda Paraiso21Simon Mantha22David B. Solit23Luis A. Diaz24Michael F. Berger25Virginia Klimek26Ross L. Levine27Ahmet Zehir28Sean M. Devlin29Elli Papaemmanuil30Computational Oncology Service, Department of Epidemiology & Biostatistics, Center for Computational Oncology, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer CenterComputational Oncology Service, Department of Epidemiology & Biostatistics, Center for Computational Oncology, Memorial Sloan Kettering Cancer CenterComputational Oncology Service, Department of Epidemiology & Biostatistics, Center for Computational Oncology, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer CenterComputational Oncology Service, Department of Epidemiology & Biostatistics, Center for Computational Oncology, Memorial Sloan Kettering Cancer CenterComputational Oncology Service, Department of Epidemiology & Biostatistics, Center for Computational Oncology, Memorial Sloan Kettering Cancer CenterComputational Oncology Service, Department of Epidemiology & Biostatistics, Center for Computational Oncology, Memorial Sloan Kettering Cancer CenterComputational Oncology Service, Department of Epidemiology & Biostatistics, Center for Computational Oncology, Memorial Sloan Kettering Cancer CenterComputational Oncology Service, Department of Epidemiology & Biostatistics, Center for Computational Oncology, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Cytogenetics Laboratory, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterCenter for Hematologic Malignancies, Memorial Sloan Kettering Cancer CenterDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer CenterDepartment of Information Systems, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterCenter for Hematologic Malignancies, Memorial Sloan Kettering Cancer CenterDepartment of Health Informatics, Memorial Sloan Kettering Cancer CenterCenter for Strategy & Innovation, Memorial Sloan Kettering Cancer CenterDepartment of Medicine, Hematology Service, Memorial Sloan Kettering Cancer CenterHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer CenterDepartment of Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Medicine, Hematology Service, Memorial Sloan Kettering Cancer CenterCenter for Hematologic Malignancies, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer CenterComputational Oncology Service, Department of Epidemiology & Biostatistics, Center for Computational Oncology, Memorial Sloan Kettering Cancer CenterPatients with solid cancers have high rates of clonal haematopoiesis associated with increased risk of secondary leukemias. Here, by using peripheral blood sequencing data from patients with solid non-hematologic cancer, the authors profile the landscape of mosaic chromosomal alterations and gene mutations, defining patients at high risk of leukemia progression.https://doi.org/10.1038/s41467-020-20565-7 |