The impact of non-coding RNAs on normal stem cells
Self-renewal and differentiation into diverse cells are two main characteristics of stem cells. These cells have important roles in development and homeostasis of different tissues and are supposed to facilitate tissue regeneration. Function of stem cells is regulated by dynamic interactions between...
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doaj-86fb450abd96419bb3764a0596f5f76a2021-09-19T04:54:32ZengElsevierBiomedicine & Pharmacotherapy0753-33222021-10-01142112050The impact of non-coding RNAs on normal stem cellsSoudeh Ghafouri-Fard0Mohammad Hossein Behzad Moghadam1Hamed Shoorei2Zahra Bahroudi3Mohammad Taheri4Afshin Taheriazam5Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranNeonatal and NICU Ward, Erfan Niayesh Hospital, Tehran, IranDepartment of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, IranDepartment of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranSkull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Corresponding authors.Department of Orthopedics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran; Corresponding authors.Self-renewal and differentiation into diverse cells are two main characteristics of stem cells. These cells have important roles in development and homeostasis of different tissues and are supposed to facilitate tissue regeneration. Function of stem cells is regulated by dynamic interactions between external signaling, epigenetic factors, and molecules that regulate expression of genes. Among the highly appreciated regulators of function of stem cells are long non-coding RNAs (lncRNAs) and microRNAs (miRNAs). Impact of miR-342-5p, miR-145, miR-1297, miR-204-5p, miR-132, miR-128-3p, hsa-miR-302, miR-26b-5p and miR-10a are among miRNAs that regulate function of stem cells. Among lncRNAs, AK141205, ANCR, MEG3, Pnky, H19, TINCR, HULC, EPB41L4A-AS1 and SNHG7 have important roles in the regulation of stem cells. In the current paper, we aimed at reviewing the importance of miRNAs and lncRNAs in differentiation of stem cells both in normal and diseased conditions. For this purpose, we searched PubMed/Medline and google scholar databases using “stem cell” AND “lncRNA”, or “long non-coding RNA”, or “microRNA” or “miRNA”.http://www.sciencedirect.com/science/article/pii/S0753332221008337LncRNAMiRNAStem cell |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Soudeh Ghafouri-Fard Mohammad Hossein Behzad Moghadam Hamed Shoorei Zahra Bahroudi Mohammad Taheri Afshin Taheriazam |
spellingShingle |
Soudeh Ghafouri-Fard Mohammad Hossein Behzad Moghadam Hamed Shoorei Zahra Bahroudi Mohammad Taheri Afshin Taheriazam The impact of non-coding RNAs on normal stem cells Biomedicine & Pharmacotherapy LncRNA MiRNA Stem cell |
author_facet |
Soudeh Ghafouri-Fard Mohammad Hossein Behzad Moghadam Hamed Shoorei Zahra Bahroudi Mohammad Taheri Afshin Taheriazam |
author_sort |
Soudeh Ghafouri-Fard |
title |
The impact of non-coding RNAs on normal stem cells |
title_short |
The impact of non-coding RNAs on normal stem cells |
title_full |
The impact of non-coding RNAs on normal stem cells |
title_fullStr |
The impact of non-coding RNAs on normal stem cells |
title_full_unstemmed |
The impact of non-coding RNAs on normal stem cells |
title_sort |
impact of non-coding rnas on normal stem cells |
publisher |
Elsevier |
series |
Biomedicine & Pharmacotherapy |
issn |
0753-3322 |
publishDate |
2021-10-01 |
description |
Self-renewal and differentiation into diverse cells are two main characteristics of stem cells. These cells have important roles in development and homeostasis of different tissues and are supposed to facilitate tissue regeneration. Function of stem cells is regulated by dynamic interactions between external signaling, epigenetic factors, and molecules that regulate expression of genes. Among the highly appreciated regulators of function of stem cells are long non-coding RNAs (lncRNAs) and microRNAs (miRNAs). Impact of miR-342-5p, miR-145, miR-1297, miR-204-5p, miR-132, miR-128-3p, hsa-miR-302, miR-26b-5p and miR-10a are among miRNAs that regulate function of stem cells. Among lncRNAs, AK141205, ANCR, MEG3, Pnky, H19, TINCR, HULC, EPB41L4A-AS1 and SNHG7 have important roles in the regulation of stem cells. In the current paper, we aimed at reviewing the importance of miRNAs and lncRNAs in differentiation of stem cells both in normal and diseased conditions. For this purpose, we searched PubMed/Medline and google scholar databases using “stem cell” AND “lncRNA”, or “long non-coding RNA”, or “microRNA” or “miRNA”. |
topic |
LncRNA MiRNA Stem cell |
url |
http://www.sciencedirect.com/science/article/pii/S0753332221008337 |
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