The Human Amnion Epithelial Cell Secretome Decreases Hepatic Fibrosis in Mice with Chronic Liver Fibrosis

The Human Amnion Epithelial Cell Secretome Decreases Hepatic Fibrosis in Mice with Chronic Liver Fibrosis

Background: Hepatic stellate cells (HSCs) are the primary collagen-secreting cells in the liver. While HSCs are the major cell type involved in the pathogenesis of liver fibrosis, hepatic macrophages also play an important role in mediating fibrogenesis and fibrosis resolution. Previously, we observ...

Full description

Bibliographic Details
Main Authors: Majid Alhomrani, Jeanne Correia, Marcus Zavou, Bryan Leaw, Nathan Kuk, Rong Xu, Mohamed I. Saad, Alexander Hodge, David W. Greening, Rebecca Lim, William Sievert
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Pharmacology
Subjects:
human amnion epithelial cells
extracellular vesicles
liver fibrosis
macrophages
anti-fibrotic therapy
secretome
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00748/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00748/full

Similar Items