Hemophagocytic syndrome and acute pancreatitis in acute systemic lupus erythematosus
Hemophagocytic syndrome (HPS) is characterized by the activation of histiocytes with prominent hemophagocytosis in bone marrow and other reticuloendothelial systems. It has two forms: primary and secondary. The precise pathogenesis of HPS is unclear but a dysregulation of macrophage–lymphocyte inter...
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doaj-87097892a1e54c04a0b9de23dee244aa2020-11-25T01:57:16ZengWolters Kluwer Medknow PublicationsJournal of Dermatology and Dermatologic Surgery2352-24102014-01-01181353710.1016/j.jdds.2014.03.004Hemophagocytic syndrome and acute pancreatitis in acute systemic lupus erythematosusBushra Alblewi0Iqbal A. Bukhari1Manal Hasan2Abdulaziz Alzahani3Raed Bukhari4Layla Bashawri5Muhammad Al Shawarby6Dermatology Department, College of Medicine, University of Dammam and King Fahd Hospital of the University, Dammam, Saudi ArabiaDermatology Department, College of Medicine, University of Dammam and King Fahd Hospital of the University, Dammam, Saudi ArabiaInternal Medicine Department, College of Medicine, University of Dammam and King Fahd Hospital of the University, Dammam, Saudi ArabiaDermatology Department, College of Medicine, University of Dammam and King Fahd Hospital of the University, Dammam, Saudi ArabiaInternal Medicine Department, College of Medicine, University of Dammam and King Fahd Hospital of the University, Dammam, Saudi ArabiaPathology Department, College of Medicine, University of Dammam and King Fahd Hospital of the University, Dammam, Saudi ArabiaPathology Department, College of Medicine, University of Dammam and King Fahd Hospital of the University, Dammam, Saudi ArabiaHemophagocytic syndrome (HPS) is characterized by the activation of histiocytes with prominent hemophagocytosis in bone marrow and other reticuloendothelial systems. It has two forms: primary and secondary. The precise pathogenesis of HPS is unclear but a dysregulation of macrophage–lymphocyte interactions with subsequent increases in the levels of both T-cell-derived and macrophage-derived cytokines has been suggested. Cardinal symptoms of HPS are prolonged high fever, hepatosplenomegaly, cytopenias, lymphadenopathy and neurological symptoms. In this report, we present a case Systemic Lupus Erythematosus associated with HPS and acute pancreatitis.http://www.sciencedirect.com/science/article/pii/S2352241014000073Hemophagocytic syndromeAcute systemic lupus erythematosusAcute pancreatitis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bushra Alblewi Iqbal A. Bukhari Manal Hasan Abdulaziz Alzahani Raed Bukhari Layla Bashawri Muhammad Al Shawarby |
spellingShingle |
Bushra Alblewi Iqbal A. Bukhari Manal Hasan Abdulaziz Alzahani Raed Bukhari Layla Bashawri Muhammad Al Shawarby Hemophagocytic syndrome and acute pancreatitis in acute systemic lupus erythematosus Journal of Dermatology and Dermatologic Surgery Hemophagocytic syndrome Acute systemic lupus erythematosus Acute pancreatitis |
author_facet |
Bushra Alblewi Iqbal A. Bukhari Manal Hasan Abdulaziz Alzahani Raed Bukhari Layla Bashawri Muhammad Al Shawarby |
author_sort |
Bushra Alblewi |
title |
Hemophagocytic syndrome and acute pancreatitis in acute systemic lupus erythematosus |
title_short |
Hemophagocytic syndrome and acute pancreatitis in acute systemic lupus erythematosus |
title_full |
Hemophagocytic syndrome and acute pancreatitis in acute systemic lupus erythematosus |
title_fullStr |
Hemophagocytic syndrome and acute pancreatitis in acute systemic lupus erythematosus |
title_full_unstemmed |
Hemophagocytic syndrome and acute pancreatitis in acute systemic lupus erythematosus |
title_sort |
hemophagocytic syndrome and acute pancreatitis in acute systemic lupus erythematosus |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Dermatology and Dermatologic Surgery |
issn |
2352-2410 |
publishDate |
2014-01-01 |
description |
Hemophagocytic syndrome (HPS) is characterized by the activation of histiocytes with prominent hemophagocytosis in bone marrow and other reticuloendothelial systems. It has two forms: primary and secondary. The precise pathogenesis of HPS is unclear but a dysregulation of macrophage–lymphocyte interactions with subsequent increases in the levels of both T-cell-derived and macrophage-derived cytokines has been suggested. Cardinal symptoms of HPS are prolonged high fever, hepatosplenomegaly, cytopenias, lymphadenopathy and neurological symptoms. In this report, we present a case Systemic Lupus Erythematosus associated with HPS and acute pancreatitis. |
topic |
Hemophagocytic syndrome Acute systemic lupus erythematosus Acute pancreatitis |
url |
http://www.sciencedirect.com/science/article/pii/S2352241014000073 |
work_keys_str_mv |
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