Synthesis of Fully Functionalized 3-Bromoazaspiro[4.5]trienones through Ugi Four-Component Reaction (Ugi-4CR) followed by ipso-Bromocyclization

Synthesis of Fully Functionalized 3-Bromoazaspiro[4.5]trienones through Ugi Four-Component Reaction (Ugi-4CR) followed by ipso-Bromocyclization

Abstract Biologically attractive azaspiro[4.5]trienones have been prepared via Ugi four-component reaction (Ugi-4CR) followed by bromine-mediated ipso-cyclization. This allows a straightforward synthetic route to a diverse collection of fully functionalized 3-bromoazaspiro[4,5]trienones in moderate...

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Bibliographic Details
Main Authors:	Saeed Balalaie, Hadiseh Bakhshaei Ghoroghaghaei, Nahid S. Alavijeh, Fatemeh Darvish, Frank Rominger, Hamid Reza Bijanzadeh
Format:	Article
Language:	English
Published:	Georg Thieme Verlag KG 2018-07-01
Series:	SynOpen
Subjects:	alkynes spiro compounds cyclization radical reaction ring closure
Online Access:	http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1610205

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