General principles in the treatment of lupus nephritis with the prevention of cardiovascular events
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of unknown etiology, which is characterized by the hyperproduction of organ-nonspecific autoantibodies to various components of the cell nucleus with the development of immunoinflammatory tissue and visceral damages. Kidney damage i...
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doaj-870fb7e081ea4cc68c283bac5241cbb82021-07-29T09:00:12ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2018-12-011244810.14412/1996-7012-2018-4-4-82119General principles in the treatment of lupus nephritis with the prevention of cardiovascular eventsТ. A. Panafidina0Т. V. Popkova1V.A. Nasonova Research Institute of Rheumatology.V.A. Nasonova Research Institute of Rheumatology.Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of unknown etiology, which is characterized by the hyperproduction of organ-nonspecific autoantibodies to various components of the cell nucleus with the development of immunoinflammatory tissue and visceral damages. Kidney damage is one of the most common severe manifestations of SLE, which develops in 40–80% of patients and, in 15–20% of them, progresses to end-stage renal failure. A renal biopsy is recommended for all patients with lupus nephritis (LN) when choosing a successful treatment policy added by immunosuppressive therapy.The paper presents treatments for LN according to its morphological class with a dosage detailed description, a route of administration, and the duration of intake of different drug groups in the induction and maintenance phases of treatment, as well as the specific features of therapy for refractory LN. Taking into account that patients with SLE in general and those with LN in particular have an increased rate of cardiovascular events, the authors have proposed exposures to traditional and specific risk factors for cardiovascular diseases.https://mrj.ima-press.net/mrj/article/view/855systemic lupus erythematosuslupus nephritisinduction phase of treatmentmaintenance phase of treatmentrefractory nephritiscardiovascular diseasestraditional risk factorsspecific risk factors |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
Т. A. Panafidina Т. V. Popkova |
spellingShingle |
Т. A. Panafidina Т. V. Popkova General principles in the treatment of lupus nephritis with the prevention of cardiovascular events Современная ревматология systemic lupus erythematosus lupus nephritis induction phase of treatment maintenance phase of treatment refractory nephritis cardiovascular diseases traditional risk factors specific risk factors |
author_facet |
Т. A. Panafidina Т. V. Popkova |
author_sort |
Т. A. Panafidina |
title |
General principles in the treatment of lupus nephritis with the prevention of cardiovascular events |
title_short |
General principles in the treatment of lupus nephritis with the prevention of cardiovascular events |
title_full |
General principles in the treatment of lupus nephritis with the prevention of cardiovascular events |
title_fullStr |
General principles in the treatment of lupus nephritis with the prevention of cardiovascular events |
title_full_unstemmed |
General principles in the treatment of lupus nephritis with the prevention of cardiovascular events |
title_sort |
general principles in the treatment of lupus nephritis with the prevention of cardiovascular events |
publisher |
IMA-PRESS LLC |
series |
Современная ревматология |
issn |
1996-7012 2310-158X |
publishDate |
2018-12-01 |
description |
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of unknown etiology, which is characterized by the hyperproduction of organ-nonspecific autoantibodies to various components of the cell nucleus with the development of immunoinflammatory tissue and visceral damages. Kidney damage is one of the most common severe manifestations of SLE, which develops in 40–80% of patients and, in 15–20% of them, progresses to end-stage renal failure. A renal biopsy is recommended for all patients with lupus nephritis (LN) when choosing a successful treatment policy added by immunosuppressive therapy.The paper presents treatments for LN according to its morphological class with a dosage detailed description, a route of administration, and the duration of intake of different drug groups in the induction and maintenance phases of treatment, as well as the specific features of therapy for refractory LN. Taking into account that patients with SLE in general and those with LN in particular have an increased rate of cardiovascular events, the authors have proposed exposures to traditional and specific risk factors for cardiovascular diseases. |
topic |
systemic lupus erythematosus lupus nephritis induction phase of treatment maintenance phase of treatment refractory nephritis cardiovascular diseases traditional risk factors specific risk factors |
url |
https://mrj.ima-press.net/mrj/article/view/855 |
work_keys_str_mv |
AT tapanafidina generalprinciplesinthetreatmentoflupusnephritiswiththepreventionofcardiovascularevents AT tvpopkova generalprinciplesinthetreatmentoflupusnephritiswiththepreventionofcardiovascularevents |
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1721250174973509632 |