Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis
Aberrant chromatin structure is often found in cancer. Here, the authors optimise super-resolution microscopy for pathological tissue and discovered a significant decompaction of chromatin folding in early carcinogenesis prior to tumour formation.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15718-7 |
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doaj-8713c6ce28ab4d18b94e1dfd7c1d15702021-05-11T09:00:48ZengNature Publishing GroupNature Communications2041-17232020-04-0111111710.1038/s41467-020-15718-7Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesisJianquan Xu0Hongqiang Ma1Hongbin Ma2Wei Jiang3Christopher A. Mela4Meihan Duan5Shimei Zhao6Chenxi Gao7Eun-Ryeong Hahm8Santana M. Lardo9Kris Troy10Ming Sun11Reet Pai12Donna B. Stolz13Lin Zhang14Shivendra Singh15Randall E. Brand16Douglas J. Hartman17Jing Hu18Sarah J. Hainer19Yang Liu20Biomedical Optical Imaging Laboratory, Departments of Medicine and Bioengineering, University of PittsburghBiomedical Optical Imaging Laboratory, Departments of Medicine and Bioengineering, University of PittsburghBiomedical Optical Imaging Laboratory, Departments of Medicine and Bioengineering, University of PittsburghBiomedical Optical Imaging Laboratory, Departments of Medicine and Bioengineering, University of PittsburghBiomedical Optical Imaging Laboratory, Departments of Medicine and Bioengineering, University of PittsburghBiomedical Optical Imaging Laboratory, Departments of Medicine and Bioengineering, University of PittsburghBiomedical Optical Imaging Laboratory, Departments of Medicine and Bioengineering, University of PittsburghDepartment of Pharmacology and Chemical Biology, University of PittsburghDepartment of Pharmacology and Chemical Biology, University of PittsburghDepartment of Biological Sciences, University of PittsburghDepartment of Biological Sciences, University of PittsburghDepartment of Cell Biology, University of PittsburghDepartment of Pathology, University of Pittsburgh School of MedicineDepartment of Cell Biology, University of PittsburghDepartment of Pharmacology and Chemical Biology, University of PittsburghDepartment of Pharmacology and Chemical Biology, University of PittsburghUniversity of Pittsburgh Hillman Cancer CenterDepartment of Pathology, University of Pittsburgh School of MedicineUniversity of Pittsburgh Hillman Cancer CenterDepartment of Biological Sciences, University of PittsburghBiomedical Optical Imaging Laboratory, Departments of Medicine and Bioengineering, University of PittsburghAberrant chromatin structure is often found in cancer. Here, the authors optimise super-resolution microscopy for pathological tissue and discovered a significant decompaction of chromatin folding in early carcinogenesis prior to tumour formation.https://doi.org/10.1038/s41467-020-15718-7 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jianquan Xu Hongqiang Ma Hongbin Ma Wei Jiang Christopher A. Mela Meihan Duan Shimei Zhao Chenxi Gao Eun-Ryeong Hahm Santana M. Lardo Kris Troy Ming Sun Reet Pai Donna B. Stolz Lin Zhang Shivendra Singh Randall E. Brand Douglas J. Hartman Jing Hu Sarah J. Hainer Yang Liu |
| spellingShingle |
Jianquan Xu Hongqiang Ma Hongbin Ma Wei Jiang Christopher A. Mela Meihan Duan Shimei Zhao Chenxi Gao Eun-Ryeong Hahm Santana M. Lardo Kris Troy Ming Sun Reet Pai Donna B. Stolz Lin Zhang Shivendra Singh Randall E. Brand Douglas J. Hartman Jing Hu Sarah J. Hainer Yang Liu Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis Nature Communications |
| author_facet |
Jianquan Xu Hongqiang Ma Hongbin Ma Wei Jiang Christopher A. Mela Meihan Duan Shimei Zhao Chenxi Gao Eun-Ryeong Hahm Santana M. Lardo Kris Troy Ming Sun Reet Pai Donna B. Stolz Lin Zhang Shivendra Singh Randall E. Brand Douglas J. Hartman Jing Hu Sarah J. Hainer Yang Liu |
| author_sort |
Jianquan Xu |
| title |
Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis |
| title_short |
Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis |
| title_full |
Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis |
| title_fullStr |
Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis |
| title_full_unstemmed |
Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis |
| title_sort |
super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-04-01 |
| description |
Aberrant chromatin structure is often found in cancer. Here, the authors optimise super-resolution microscopy for pathological tissue and discovered a significant decompaction of chromatin folding in early carcinogenesis prior to tumour formation. |
| url |
https://doi.org/10.1038/s41467-020-15718-7 |
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