Milk exosomes: Nature's abundant nanoplatform for theranostic applications
Exosomes are a unique subpopulation of naturally occurring extracellular vesicles which are smaller intracellular membrane nanoparticle vesicles. Exosomes have proven to be excellent nanocarriers for carrying lipids, proteins, mRNAs, non-coding RNAs, and DNAs, and disseminating long-distance interce...
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doaj-87173bb3e39643158897bd462bebf8a82021-05-08T04:23:36ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2021-08-016824792490Milk exosomes: Nature's abundant nanoplatform for theranostic applicationsBenilde Adriano0Nycol M. Cotto1Neeraj Chauhan2Meena Jaggi3Subhash C. Chauhan4Murali M. Yallapu5Department of Immunology and Microbiology, School of Medicine, The University of Texas Rio Grande Valley, McAllen, TX, 78504, USA; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, 78504, USADepartment of Immunology and Microbiology, School of Medicine, The University of Texas Rio Grande Valley, McAllen, TX, 78504, USA; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, 78504, USADepartment of Immunology and Microbiology, School of Medicine, The University of Texas Rio Grande Valley, McAllen, TX, 78504, USA; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, 78504, USADepartment of Immunology and Microbiology, School of Medicine, The University of Texas Rio Grande Valley, McAllen, TX, 78504, USA; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, 78504, USADepartment of Immunology and Microbiology, School of Medicine, The University of Texas Rio Grande Valley, McAllen, TX, 78504, USA; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, 78504, USADepartment of Immunology and Microbiology, School of Medicine, The University of Texas Rio Grande Valley, McAllen, TX, 78504, USA; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, 78504, USA; Corresponding author. Department of Immunology and Microbiology Member, South Texas Center of Excellence in Cancer Research School of Medicine, The University of Texas Rio Grande Valley, 5300 North L Street, McAllen, TX, 78504, USA.Exosomes are a unique subpopulation of naturally occurring extracellular vesicles which are smaller intracellular membrane nanoparticle vesicles. Exosomes have proven to be excellent nanocarriers for carrying lipids, proteins, mRNAs, non-coding RNAs, and DNAs, and disseminating long-distance intercellular communications in various biological processes. Among various cell-line or biological fluid derived exosomes, milk exosomes are abundant in nature and exhibit many nanocarrier characteristics favorable for theranostic applications. To be an effective delivery carrier for their clinical translation, exosomes must inbuilt loading, release, targeting, and imaging/tracking characteristics. Considering the unmet gaps of milk exosomes in theranostic technology it is essential to focus the current review on drug delivery and imaging applications. This review delineates the efficiency of exosomes to load therapeutic or imaging agents and their successful delivery approaches. It is emphasized on possible modifications of exosomes towards increasing the stability and delivery of agents. This article also summarizes the specific applications and the process of developing milk exosomes as a future pharmaceutical drug delivery vehicle.http://www.sciencedirect.com/science/article/pii/S2452199X2100013XMilk exosomesExtracellular vesiclesDrug deliveryImaging agentsTheranostic applications |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Benilde Adriano Nycol M. Cotto Neeraj Chauhan Meena Jaggi Subhash C. Chauhan Murali M. Yallapu |
spellingShingle |
Benilde Adriano Nycol M. Cotto Neeraj Chauhan Meena Jaggi Subhash C. Chauhan Murali M. Yallapu Milk exosomes: Nature's abundant nanoplatform for theranostic applications Bioactive Materials Milk exosomes Extracellular vesicles Drug delivery Imaging agents Theranostic applications |
author_facet |
Benilde Adriano Nycol M. Cotto Neeraj Chauhan Meena Jaggi Subhash C. Chauhan Murali M. Yallapu |
author_sort |
Benilde Adriano |
title |
Milk exosomes: Nature's abundant nanoplatform for theranostic applications |
title_short |
Milk exosomes: Nature's abundant nanoplatform for theranostic applications |
title_full |
Milk exosomes: Nature's abundant nanoplatform for theranostic applications |
title_fullStr |
Milk exosomes: Nature's abundant nanoplatform for theranostic applications |
title_full_unstemmed |
Milk exosomes: Nature's abundant nanoplatform for theranostic applications |
title_sort |
milk exosomes: nature's abundant nanoplatform for theranostic applications |
publisher |
KeAi Communications Co., Ltd. |
series |
Bioactive Materials |
issn |
2452-199X |
publishDate |
2021-08-01 |
description |
Exosomes are a unique subpopulation of naturally occurring extracellular vesicles which are smaller intracellular membrane nanoparticle vesicles. Exosomes have proven to be excellent nanocarriers for carrying lipids, proteins, mRNAs, non-coding RNAs, and DNAs, and disseminating long-distance intercellular communications in various biological processes. Among various cell-line or biological fluid derived exosomes, milk exosomes are abundant in nature and exhibit many nanocarrier characteristics favorable for theranostic applications. To be an effective delivery carrier for their clinical translation, exosomes must inbuilt loading, release, targeting, and imaging/tracking characteristics. Considering the unmet gaps of milk exosomes in theranostic technology it is essential to focus the current review on drug delivery and imaging applications. This review delineates the efficiency of exosomes to load therapeutic or imaging agents and their successful delivery approaches. It is emphasized on possible modifications of exosomes towards increasing the stability and delivery of agents. This article also summarizes the specific applications and the process of developing milk exosomes as a future pharmaceutical drug delivery vehicle. |
topic |
Milk exosomes Extracellular vesicles Drug delivery Imaging agents Theranostic applications |
url |
http://www.sciencedirect.com/science/article/pii/S2452199X2100013X |
work_keys_str_mv |
AT benildeadriano milkexosomesnaturesabundantnanoplatformfortheranosticapplications AT nycolmcotto milkexosomesnaturesabundantnanoplatformfortheranosticapplications AT neerajchauhan milkexosomesnaturesabundantnanoplatformfortheranosticapplications AT meenajaggi milkexosomesnaturesabundantnanoplatformfortheranosticapplications AT subhashcchauhan milkexosomesnaturesabundantnanoplatformfortheranosticapplications AT muralimyallapu milkexosomesnaturesabundantnanoplatformfortheranosticapplications |
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1721455053947011072 |