Low-Temperature Photothermal Therapy: Strategies and Applications
Although photothermal therapy (PTT) with the assistance of nanotechnology has been considered as an indispensable strategy in the biomedical field, it still encounters some severe problems that need to be solved. Excessive heat can induce treated cells to develop thermal resistance, and thus, the ef...
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doaj-87231239d89b4563bfc1b98d177045592021-05-24T12:55:31ZengAmerican Association for the Advancement of ScienceResearch2639-52742021-01-01202110.34133/2021/9816594Low-Temperature Photothermal Therapy: Strategies and ApplicationsXiulin Yi0Qiu-Yi Duan1Fu-Gen Wu2State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,2 Sipailou Road, Nanjing 210096,ChinaState Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,2 Sipailou Road, Nanjing 210096,ChinaState Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,2 Sipailou Road, Nanjing 210096,ChinaAlthough photothermal therapy (PTT) with the assistance of nanotechnology has been considered as an indispensable strategy in the biomedical field, it still encounters some severe problems that need to be solved. Excessive heat can induce treated cells to develop thermal resistance, and thus, the efficacy of PTT may be dramatically decreased. In the meantime, the uncontrollable diffusion of heat can pose a threat to the surrounding healthy tissues. Recently, low-temperature PTT (also known as mild PTT or mild-temperature PTT) has demonstrated its remarkable capacity of conquering these obstacles and has shown excellent performance in bacterial elimination, wound healing, and cancer treatments. Herein, we summarize the recently proposed strategies for achieving low-temperature PTT based on nanomaterials and introduce the synthesis, characteristics, and applications of these nanoplatforms. Additionally, the combination of PTT and other therapeutic modalities for defeating cancers and the synergistic cancer therapeutic effect of the combined treatments are discussed. Finally, the current limitations and future directions are proposed for inspiring more researchers to make contributions to promoting low-temperature PTT toward more successful preclinical and clinical disease treatments.http://dx.doi.org/10.34133/2021/9816594 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiulin Yi Qiu-Yi Duan Fu-Gen Wu |
spellingShingle |
Xiulin Yi Qiu-Yi Duan Fu-Gen Wu Low-Temperature Photothermal Therapy: Strategies and Applications Research |
author_facet |
Xiulin Yi Qiu-Yi Duan Fu-Gen Wu |
author_sort |
Xiulin Yi |
title |
Low-Temperature Photothermal Therapy: Strategies and Applications |
title_short |
Low-Temperature Photothermal Therapy: Strategies and Applications |
title_full |
Low-Temperature Photothermal Therapy: Strategies and Applications |
title_fullStr |
Low-Temperature Photothermal Therapy: Strategies and Applications |
title_full_unstemmed |
Low-Temperature Photothermal Therapy: Strategies and Applications |
title_sort |
low-temperature photothermal therapy: strategies and applications |
publisher |
American Association for the Advancement of Science |
series |
Research |
issn |
2639-5274 |
publishDate |
2021-01-01 |
description |
Although photothermal therapy (PTT) with the assistance of nanotechnology has been considered as an indispensable strategy in the biomedical field, it still encounters some severe problems that need to be solved. Excessive heat can induce treated cells to develop thermal resistance, and thus, the efficacy of PTT may be dramatically decreased. In the meantime, the uncontrollable diffusion of heat can pose a threat to the surrounding healthy tissues. Recently, low-temperature PTT (also known as mild PTT or mild-temperature PTT) has demonstrated its remarkable capacity of conquering these obstacles and has shown excellent performance in bacterial elimination, wound healing, and cancer treatments. Herein, we summarize the recently proposed strategies for achieving low-temperature PTT based on nanomaterials and introduce the synthesis, characteristics, and applications of these nanoplatforms. Additionally, the combination of PTT and other therapeutic modalities for defeating cancers and the synergistic cancer therapeutic effect of the combined treatments are discussed. Finally, the current limitations and future directions are proposed for inspiring more researchers to make contributions to promoting low-temperature PTT toward more successful preclinical and clinical disease treatments. |
url |
http://dx.doi.org/10.34133/2021/9816594 |
work_keys_str_mv |
AT xiulinyi lowtemperaturephotothermaltherapystrategiesandapplications AT qiuyiduan lowtemperaturephotothermaltherapystrategiesandapplications AT fugenwu lowtemperaturephotothermaltherapystrategiesandapplications |
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